Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol)
This paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of Mn =2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected β-Alanine and L-Alanine. NMR showed full conversion for protected β-Alanine, and...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Budapest University of Technology
2022-09-01
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Series: | eXPRESS Polymer Letters |
Subjects: | |
Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0011841&mi=cd |
Summary: | This paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of Mn =2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected β-Alanine and L-Alanine. NMR showed full conversion for protected β-Alanine, and MALDI-ToF demonstrated the purity of the product. After deprotection, the desired diamine-functionalized PEG was obtained. Protected L-Alanine did not reach full conversion by NMR, likely due to the steric hindrance of its methyl side group. |
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ISSN: | 1788-618X |