Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol)
This paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of Mn =2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected β-Alanine and L-Alanine. NMR showed full conversion for protected β-Alanine, and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Budapest University of Technology
2022-09-01
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| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0011841&mi=cd |
| _version_ | 1811324159600361472 |
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| author | Judit Eva Puskas Enikő Krisch Aswathy Sasidharan Pillai Prajakatta Mulay |
| author_facet | Judit Eva Puskas Enikő Krisch Aswathy Sasidharan Pillai Prajakatta Mulay |
| author_sort | Judit Eva Puskas |
| collection | DOAJ |
| description | This paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of Mn =2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected β-Alanine and L-Alanine. NMR showed full conversion for protected β-Alanine, and MALDI-ToF demonstrated the purity of the product. After deprotection, the desired diamine-functionalized PEG was obtained. Protected L-Alanine did not reach full conversion by NMR, likely due to the steric hindrance of its methyl side group. |
| first_indexed | 2024-04-13T14:09:20Z |
| format | Article |
| id | doaj.art-eb49e96533fd419bb0e2a191e2a10561 |
| institution | Directory Open Access Journal |
| issn | 1788-618X |
| language | English |
| last_indexed | 2024-04-13T14:09:20Z |
| publishDate | 2022-09-01 |
| publisher | Budapest University of Technology |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj.art-eb49e96533fd419bb0e2a191e2a105612022-12-22T02:43:50ZengBudapest University of TechnologyeXPRESS Polymer Letters1788-618X2022-09-0116993393810.3144/expresspolymlett.2022.68Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol)Judit Eva PuskasEnikő KrischAswathy Sasidharan PillaiPrajakatta MulayThis paper presents a new method for the amine-functionalization of poly(ethylene glycol) (PEG) of Mn =2050 g/mol via Candida antarctica lipase B (CALB)-catalyzed esterification of tert-butyloxycarbonyl (tBOC)-protected β-Alanine and L-Alanine. NMR showed full conversion for protected β-Alanine, and MALDI-ToF demonstrated the purity of the product. After deprotection, the desired diamine-functionalized PEG was obtained. Protected L-Alanine did not reach full conversion by NMR, likely due to the steric hindrance of its methyl side group.http://www.expresspolymlett.com/letolt.php?file=EPL-0011841&mi=cdpolymer synthesis, molecular engineeringtailor-made polymersbiocompatible polymerspoly(ethylene glycol) diamineenzyme catalysis |
| spellingShingle | Judit Eva Puskas Enikő Krisch Aswathy Sasidharan Pillai Prajakatta Mulay Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol) eXPRESS Polymer Letters polymer synthesis, molecular engineering tailor-made polymers biocompatible polymers poly(ethylene glycol) diamine enzyme catalysis |
| title | Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol) |
| title_full | Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol) |
| title_fullStr | Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol) |
| title_full_unstemmed | Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol) |
| title_short | Enzyme-catalyzed amine-functionalization of poly(ethylene-glycol) |
| title_sort | enzyme catalyzed amine functionalization of poly ethylene glycol |
| topic | polymer synthesis, molecular engineering tailor-made polymers biocompatible polymers poly(ethylene glycol) diamine enzyme catalysis |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0011841&mi=cd |
| work_keys_str_mv | AT juditevapuskas enzymecatalyzedaminefunctionalizationofpolyethyleneglycol AT enikokrisch enzymecatalyzedaminefunctionalizationofpolyethyleneglycol AT aswathysasidharanpillai enzymecatalyzedaminefunctionalizationofpolyethyleneglycol AT prajakattamulay enzymecatalyzedaminefunctionalizationofpolyethyleneglycol |