Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment
Inflammatory bowel disease (IBD) is a group of intestinal disorders which cause prolonged digestive tract inflammation. The early diagnosis of IBD through the detection of its biomarkers (including tumor necrosis factor alpha, C-reactive protein, cytokines and microRNAs) and imaging agents is a chal...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Sensing and Bio-Sensing Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214180421000222 |
| _version_ | 1818594728436826112 |
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| author | Mahmood Barani Abbas Rahdar Saman Sargazi Mohammad Sadegh Amiri Preetam Kumar Sharma Nikhil Bhalla |
| author_facet | Mahmood Barani Abbas Rahdar Saman Sargazi Mohammad Sadegh Amiri Preetam Kumar Sharma Nikhil Bhalla |
| author_sort | Mahmood Barani |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a group of intestinal disorders which cause prolonged digestive tract inflammation. The early diagnosis of IBD through the detection of its biomarkers (including tumor necrosis factor alpha, C-reactive protein, cytokines and microRNAs) and imaging agents is a challenge. Nanotechnology enabled biosensors and enhanced image contrasting chemicals for diagnosis offer promises for an affordable, early and reliable confirmation of the disease and type thereof. Moreover, engineered nanoparticles (NPs) can also be used to deliver active drug agents directly to the region of inflammation. Major advantages of the targeted drug delivery are low dosage drug requirement due to localized/guided delivery and minimal side effects to other organs by the drug. Here, we present a mini review about different engineered nanostructures (Au NPs, Graphene, Quantum dots, inorganic NPs, etc.) and plant-based nanoparticles for the detection, imaging and treatment of IBD. |
| first_indexed | 2024-12-16T11:04:44Z |
| format | Article |
| id | doaj.art-eb4a9f316bea4f4aaa9dc54e20805050 |
| institution | Directory Open Access Journal |
| issn | 2214-1804 |
| language | English |
| last_indexed | 2024-12-16T11:04:44Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensing and Bio-Sensing Research |
| spelling | doaj.art-eb4a9f316bea4f4aaa9dc54e208050502022-12-21T22:33:54ZengElsevierSensing and Bio-Sensing Research2214-18042021-06-0132100417Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatmentMahmood Barani0Abbas Rahdar1Saman Sargazi2Mohammad Sadegh Amiri3Preetam Kumar Sharma4Nikhil Bhalla5Department of Chemistry, Shahid Bahonar University of Kerman, 76169-14111 Kerman, Iran; Corresponding author at: Nanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, Ulster University, Jordanstown Shore Road, BT37 0QB, Northern Ireland, United Kingdom.Department of Physics, Faculty of Science, University of Zabol, 538-98615 Zabol, Iran; Corresponding author at: Nanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, Ulster University, Jordanstown Shore Road, BT37 0QB, Northern Ireland, United Kingdom.Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, 98167-43463, IranDepartment of Biology, Payame Noor University, Tehran, IranNanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, Ulster University, Jordanstown, Shore Road, BT37 0QB, Northern Ireland, United Kingdom; Healthcare Technology Hub, Ulster University, Jordanstown, Shore Road, BT37 0QB, Northern Ireland, United KingdomNanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, Ulster University, Jordanstown, Shore Road, BT37 0QB, Northern Ireland, United Kingdom; Healthcare Technology Hub, Ulster University, Jordanstown, Shore Road, BT37 0QB, Northern Ireland, United Kingdom; Corresponding author at: Nanotechnology and Integrated Bioengineering Centre (NIBEC), School of Engineering, Ulster University, Jordanstown Shore Road, BT37 0QB, Northern Ireland, United Kingdom.Inflammatory bowel disease (IBD) is a group of intestinal disorders which cause prolonged digestive tract inflammation. The early diagnosis of IBD through the detection of its biomarkers (including tumor necrosis factor alpha, C-reactive protein, cytokines and microRNAs) and imaging agents is a challenge. Nanotechnology enabled biosensors and enhanced image contrasting chemicals for diagnosis offer promises for an affordable, early and reliable confirmation of the disease and type thereof. Moreover, engineered nanoparticles (NPs) can also be used to deliver active drug agents directly to the region of inflammation. Major advantages of the targeted drug delivery are low dosage drug requirement due to localized/guided delivery and minimal side effects to other organs by the drug. Here, we present a mini review about different engineered nanostructures (Au NPs, Graphene, Quantum dots, inorganic NPs, etc.) and plant-based nanoparticles for the detection, imaging and treatment of IBD.http://www.sciencedirect.com/science/article/pii/S2214180421000222Inflammatory bowel diseaseNanotechnologyDiagnosisBiosensorsImagingDrug-delivery |
| spellingShingle | Mahmood Barani Abbas Rahdar Saman Sargazi Mohammad Sadegh Amiri Preetam Kumar Sharma Nikhil Bhalla Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment Sensing and Bio-Sensing Research Inflammatory bowel disease Nanotechnology Diagnosis Biosensors Imaging Drug-delivery |
| title | Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment |
| title_full | Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment |
| title_fullStr | Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment |
| title_full_unstemmed | Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment |
| title_short | Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment |
| title_sort | nanotechnology for inflammatory bowel disease management detection imaging and treatment |
| topic | Inflammatory bowel disease Nanotechnology Diagnosis Biosensors Imaging Drug-delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2214180421000222 |
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