A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model?
Background: Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. Objectives: To found, which of the toxicities is the first side effect of CP. Materials and Methods:...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2012-10-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/JNP-1-190.pdf |
| _version_ | 1797827945031532544 |
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| author | Mehdi Nematbakhsh Farzaneh Ashrafi Zahra Pezeshki Zahra Fatahi Fariborz Kianpoor Mohammad-Hossein Sanei Ardeshir Talebi |
| author_facet | Mehdi Nematbakhsh Farzaneh Ashrafi Zahra Pezeshki Zahra Fatahi Fariborz Kianpoor Mohammad-Hossein Sanei Ardeshir Talebi |
| author_sort | Mehdi Nematbakhsh |
| collection | DOAJ |
| description | Background: Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. Objectives: To found, which of the toxicities is the first side effect of CP. Materials and Methods: we conducted a pilot research on 12 adult male Wistar rats. Results: One week after CP administration, the induced toxicity was observed clearly in kidney tissue. The only abnormality that observed in testis tissue was very small degree of hyaline casts. However, no damage and other abnormality were detected in the liver tissue. Conclusions: According to these findings, in clinic, first special attention must be made on kidneys during chemotherapy with CP. However, the duration of experiment is suggested to be extended to obtain hepatoxicity or testicular toxicity model in experimental animal in laboratories. Moreover, different dose of CP should be used to study the first side effect in animal model. |
| first_indexed | 2024-04-09T12:56:32Z |
| format | Article |
| id | doaj.art-eb4e42c376b943538223dea510a4c263 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:56:32Z |
| publishDate | 2012-10-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-eb4e42c376b943538223dea510a4c2632023-05-13T11:44:12ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192012-10-011319019310.5812/nephropathol.8122JNP_20130220181724A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model?Mehdi Nematbakhsh0Farzaneh Ashrafi1Zahra Pezeshki2Zahra Fatahi3Fariborz Kianpoor4Mohammad-Hossein Sanei5Ardeshir Talebi6Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran.Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran.Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran.Clinical Pathologist, Isfahan, Iran.Water & Electrolytes Research Center, Isfahan University of Medical Sciences Isfahan, Iran.Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Clinical Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.Background: Cisplatin (CP) is widely used in clinic to treat the solid tumors. However, CP is associated with some major side effects including nephrotoxicity, hepatoxicity, and testicular toxicity. Objectives: To found, which of the toxicities is the first side effect of CP. Materials and Methods: we conducted a pilot research on 12 adult male Wistar rats. Results: One week after CP administration, the induced toxicity was observed clearly in kidney tissue. The only abnormality that observed in testis tissue was very small degree of hyaline casts. However, no damage and other abnormality were detected in the liver tissue. Conclusions: According to these findings, in clinic, first special attention must be made on kidneys during chemotherapy with CP. However, the duration of experiment is suggested to be extended to obtain hepatoxicity or testicular toxicity model in experimental animal in laboratories. Moreover, different dose of CP should be used to study the first side effect in animal model.https://nephropathol.com/PDF/JNP-1-190.pdfnephrotoxicityhepatoxicitycisplatintoxicity |
| spellingShingle | Mehdi Nematbakhsh Farzaneh Ashrafi Zahra Pezeshki Zahra Fatahi Fariborz Kianpoor Mohammad-Hossein Sanei Ardeshir Talebi A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model? Journal of Nephropathology nephrotoxicity hepatoxicity cisplatin toxicity |
| title | A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model? |
| title_full | A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model? |
| title_fullStr | A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model? |
| title_full_unstemmed | A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model? |
| title_short | A histopathological study of nephrotoxicity, hepatoxicity or testicular toxicity: Which one is the first observation as side effect of Cisplatin-induced toxicity in animal model? |
| title_sort | histopathological study of nephrotoxicity hepatoxicity or testicular toxicity which one is the first observation as side effect of cisplatin induced toxicity in animal model |
| topic | nephrotoxicity hepatoxicity cisplatin toxicity |
| url | https://nephropathol.com/PDF/JNP-1-190.pdf |
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