Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment
The brain is a complex 3-dimensional structure, the organization of which provides a local environment that directly influences the survival, proliferation, differentiation, migration, and plasticity of neurons. To probe the effects of damage and disease on these cells, a synthetic environment is ne...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219305334 |
| _version_ | 1811326173412589568 |
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| author | Arianna Cembran Kiara F. Bruggeman Richard J. Williams Clare L. Parish David R. Nisbet |
| author_facet | Arianna Cembran Kiara F. Bruggeman Richard J. Williams Clare L. Parish David R. Nisbet |
| author_sort | Arianna Cembran |
| collection | DOAJ |
| description | The brain is a complex 3-dimensional structure, the organization of which provides a local environment that directly influences the survival, proliferation, differentiation, migration, and plasticity of neurons. To probe the effects of damage and disease on these cells, a synthetic environment is needed. Three-dimensional culturing of stem cells, neural progenitors, and neurons within fabricated biomaterials has demonstrated superior biomimetic properties over conventional 2-dimensional cultureware, offering direct recapitulation of both cell-cell and cell-extracellular matrix interactions. Within this review we address the benefits of deploying biomaterials as advanced cell culture tools capable of influencing neuronal fate and as in vitro models of the native in vivo microenvironment. We highlight recent and promising biomaterials approaches toward understanding neural network and their function relevant to neurodevelopment and provide our perspective on how these materials can be engineered and programmed to study both the healthy and diseased nervous system. : Biomaterials; Cellular Neuroscience; Materials Science; Neuroscience Subject Areas: Biomaterials, Cellular Neuroscience, Materials Science, Neuroscience |
| first_indexed | 2024-04-13T14:45:38Z |
| format | Article |
| id | doaj.art-eb4f31e66f414d72b3ed5e28ca7676de |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-13T14:45:38Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-eb4f31e66f414d72b3ed5e28ca7676de2022-12-22T02:42:46ZengElsevieriScience2589-00422020-01-01231Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural EnvironmentArianna Cembran0Kiara F. Bruggeman1Richard J. Williams2Clare L. Parish3David R. Nisbet4Laboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, The Australian National University, Canberra, ACT 2600, AustraliaLaboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, The Australian National University, Canberra, ACT 2600, AustraliaSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, AustraliaThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Melbourne, VIC 3010, Australia; Corresponding authorLaboratory of Advanced Biomaterials, Research School of Electrical, Energy and Materials Engineering, The Australian National University, Canberra, ACT 2600, Australia; Corresponding authorThe brain is a complex 3-dimensional structure, the organization of which provides a local environment that directly influences the survival, proliferation, differentiation, migration, and plasticity of neurons. To probe the effects of damage and disease on these cells, a synthetic environment is needed. Three-dimensional culturing of stem cells, neural progenitors, and neurons within fabricated biomaterials has demonstrated superior biomimetic properties over conventional 2-dimensional cultureware, offering direct recapitulation of both cell-cell and cell-extracellular matrix interactions. Within this review we address the benefits of deploying biomaterials as advanced cell culture tools capable of influencing neuronal fate and as in vitro models of the native in vivo microenvironment. We highlight recent and promising biomaterials approaches toward understanding neural network and their function relevant to neurodevelopment and provide our perspective on how these materials can be engineered and programmed to study both the healthy and diseased nervous system. : Biomaterials; Cellular Neuroscience; Materials Science; Neuroscience Subject Areas: Biomaterials, Cellular Neuroscience, Materials Science, Neurosciencehttp://www.sciencedirect.com/science/article/pii/S2589004219305334 |
| spellingShingle | Arianna Cembran Kiara F. Bruggeman Richard J. Williams Clare L. Parish David R. Nisbet Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment iScience |
| title | Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment |
| title_full | Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment |
| title_fullStr | Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment |
| title_full_unstemmed | Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment |
| title_short | Biomimetic Materials and Their Utility in Modeling the 3-Dimensional Neural Environment |
| title_sort | biomimetic materials and their utility in modeling the 3 dimensional neural environment |
| url | http://www.sciencedirect.com/science/article/pii/S2589004219305334 |
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