The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

The Discovery of Insulin-Regulated Aminopeptidase (IRAP) Inhibitors: A Literature Review

Insulin-Regulated Aminopeptidase (IRAP, EC 3.4.11.3) is a multi-tasking member of the M1 family of zinc aminopeptidases. Among its diverse biological functions, IRAP is a regulator of oxytocin levels during late stages of pregnancy, it affects cellular glucose uptake by trafficking of the glucose tr...

Full description

Bibliographic Details
Main Authors:	Dimitris Georgiadis, Angeliki Ziotopoulou, Eleni Kaloumenou, Angelos Lelis, Antonia Papasava
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-09-01
Series:	Frontiers in Pharmacology
Subjects:	inhibitor insulin-regulated aminopeptidase inhibitor selectivity aminopeptidase structure-activity relationships
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.585838/full

Similar Items

Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain
by: Yoshikuni Goto, et al.
Published: (2020-07-01)

Marine Invertebrates: A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families
by: Isel Pascual Alonso, et al.
Published: (2023-04-01)

Purification and partial characterization of Phaseolus vulgaris seed aminopeptidase
by: A.P. Abdala, et al.
Published: (1999-12-01)

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases
by: Emmanuel Salomon, et al.
Published: (2018-10-01)

Discovery of Novel Tetrahydro-β-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers
by: Xiaoyan Xing, et al.
Published: (2022-05-01)

Discovery of Selective Inhibitor Leads by Targeting an Allosteric Site in Insulin-Regulated Aminopeptidase
by: Ioannis Temponeras, et al.
Published: (2021-06-01)

Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds
by: Weronika Wanat, et al.
Published: (2019-09-01)

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Benzopyran-Based Inhibitors
by: Sudarsana Reddy Vanga, et al.
Published: (2021-04-01)

Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines—Synthesis and Evaluation
by: Karin Engen, et al.
Published: (2024-02-01)

Is There an Interplay Between the Functional Domains of IRAP?
by: Anika Vear, et al.
Published: (2020-09-01)

Dipeptidyl aminopeptidases : [electronic book] basic science and clinical applications /
by: Lendeckel, Uwe, et al.
Published: (2006)

The Discovery of New Inhibitors of Insulin-Regulated Aminopeptidase by a High-Throughput Screening of 400,000 Drug-like Compounds
by: Johan Gising, et al.
Published: (2024-04-01)

Insulin-regulated aminopeptidase contributes to setting the intensity of FcR-mediated inflammation
by: Manuela Bratti, et al.
Published: (2022-10-01)

The Type of Fat in the Diet Influences the Behavior and the Relationship Between Cystinyl and Alanyl Aminopeptidase Activities in Frontal Cortex, Liver, and Plasma
by: Ana Belén Segarra, et al.
Published: (2020-05-01)

Phosphonic Acid Analogs of Fluorophenylalanines as Inhibitors of Human and Porcine Aminopeptidases N: Validation of the Importance of the Substitution of the Aromatic Ring
by: Weronika Wanat, et al.
Published: (2020-04-01)

Inferior Outcome of Addition of the Aminopeptidase Inhibitor Tosedostat to Standard Intensive Treatment for Elderly Patients with AML and High Risk MDS
by: Jeroen Janssen, et al.
Published: (2021-02-01)

Hydrogen Peroxide Induced Toxicity Is Reversed by the Macrocyclic IRAP-Inhibitor HA08 in Primary Hippocampal Cell Cultures
by: Frida Stam, et al.
Published: (2022-10-01)

Systematic Review and Meta-Analyses of Aminopeptidases as Prognostic Biomarkers in Amyotrophic Lateral Sclerosis
by: Bárbara Teruel-Peña, et al.
Published: (2023-04-01)

Arginine specific aminopeptidase from Lactobacillus brevis
by: Arya Nandan, et al.
Published: (2010-12-01)

Microginins from a Microcystis sp. Bloom Material Collected from the Kishon Reservoir, Israel
by: Anat Lodin-Friedman, et al.
Published: (2018-03-01)

Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen
by: Juho J. Miettinen, et al.
Published: (2021-03-01)

Characterization of aminopeptidase encoding gene anp-1 and its association with development in Caenorhabditis elegans
by: Shanchun Su, et al.
Published: (2019-11-01)

KBE009: A Bestatin-Like Inhibitor of the <i>Trypanosoma cruzi</i> Acidic M17 Aminopeptidase with In Vitro Anti-Trypanosomal Activity
by: Jorge González-Bacerio, et al.
Published: (2021-10-01)

Aminopeptidases in Mycelium and Growth Medium of Streptomyces rimosus Strains
by: Jasminka Špoljarić, et al.
Published: (2009-01-01)

Synthesis of 2-{[2-(2-oxo-1-azacycloalkyl)acetamido]phenoxy}acetic acids and their activity as aminopeptidase M inhibitors
by: OLDŘICH FARSA, et al.
Published: (2008-08-01)

Synthesis of 2-{[2-(2-oxo-1-azacycloalkyl)acetamido]phenoxy}acetic acids and their activity as aminopeptidase M inhibitors
by: Farsa Oldřich, et al.
Published: (2008-01-01)

Aminopeptidase N Inhibitors as Pointers for Overcoming Antitumor Treatment Resistance
by: Oldřich Farsa, et al.
Published: (2022-08-01)

Therapeutic effect on Alveolar echinococcosis by targeting EM-Leucine aminopeptidase
by: Zhen Zhou, et al.
Published: (2022-10-01)

Editorial: Physiological, Pathological Roles and Pharmacology of Insulin Regulated Aminopeptidase
by: Siew Yeen Chai, et al.
Published: (2021-04-01)

Aminopeptidases in Cardiovascular and Renal Function. Role as Predictive Renal Injury Biomarkers
by: Félix Vargas, et al.
Published: (2020-08-01)

Recent Progress of Activity-Based Fluorescent Probes for Imaging Leucine Aminopeptidase
by: Ze-Jun Li, et al.
Published: (2023-07-01)

Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats
by: Sebastián Montoro-Molina, et al.
Published: (2018-11-01)

A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling
by: Lance K. Blevins, et al.
Published: (2017-11-01)

Correlation Between Proteolytic Enzymes and Microangiogenesis in Degenerative Intervertebral Disc Nucleus
by: Dong Chen, et al.
Published: (2021-07-01)

Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice
by: Gabriel R. Estrela, et al.
Published: (2020-05-01)

MapB Protein is the Essential Methionine Aminopeptidase in <i>Mycobacterium tuberculosis</i>
by: Miriam Vanunu, et al.
Published: (2019-04-01)

The Role of GABA and Insulin Regulated Aminopeptidase on Insulin Resistance and GLUT4 in Prediabetes and Type 2 Diabetes Mellitus
by: Ismael Sadeq Khashan, et al.
Published: (2024-04-01)

Placental Leucine Aminopeptidase as a Potential Specific Urine Biomarker for Invasive Ovarian Cancer
by: Tetsuya Matsukawa, et al.
Published: (2021-12-01)

Structure-Function and Industrial Relevance of Bacterial Aminopeptidase P
by: Muhamad Nadzmi Omar, et al.
Published: (2021-09-01)

Synthesis and Inhibitory Studies of Phosphonic Acid Analogues of Homophenylalanine and Phenylalanine towards Alanyl Aminopeptidases
by: Weronika Wanat, et al.
Published: (2020-09-01)