Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study

Simultaneous determination of ivabradine and N-desmethylivabradine in human plasma and urine using a LC-MS/MS method: application to a pharmacokinetic study

A sensitive and specific liquid-chromatography tandem mass spectrometry (LC-MS/MS) assay has been developed and validated for the simultaneous quantification of ivabradine and its active metabolite N-desmethylivabradine in human plasma and urine. The assay employed a single liquid–liquid extraction...

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Bibliographic Details
Main Authors: Chengtao Lu, Yanyan Jia, Jing Yang, Xin Jin, Ying Song, Wenxing Liu, Yi Ding, Xiaoli Sun, Aidong Wen
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ivabradine
N-desmethylivabradine
Pharmacokinetics
LC-MS/MS
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383512000251

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