Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications
Abstract Background The joint effect of platelet and other modifiers on the risk of pregnancy complications is unknown. This study investigated whether platelet count (PC) and total homocysteine (tHcy) level have a synergistic effect on the incidence of pregnancy complications in a Chinese populatio...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-023-16027-6 |
| _version_ | 1797811306664820736 |
|---|---|
| author | Bin Yu Bin Zhang Xiaoya Han Wei Long Wenbo Zhou Xiaosong Yuan |
| author_facet | Bin Yu Bin Zhang Xiaoya Han Wei Long Wenbo Zhou Xiaosong Yuan |
| author_sort | Bin Yu |
| collection | DOAJ |
| description | Abstract Background The joint effect of platelet and other modifiers on the risk of pregnancy complications is unknown. This study investigated whether platelet count (PC) and total homocysteine (tHcy) level have a synergistic effect on the incidence of pregnancy complications in a Chinese population. Methods Total 11,553 consecutive pregnant women who received whole blood cell and biochemical tests at the time of admission for labor in Changzhou Maternal and Child Health Care Hospital were analyzed. The primary outcome was the prevalence of pregnancy complications: gestational diabetes mellitus (GDM), intrahepatic cholestasis of pregnancy (ICP), pre-eclampsia (PE), and pregnancy induced hypertension (PIH). Results The prevalence of GDM, ICP, PE, and PIH was 8.4%, 6.2%, 3.4%, and 2.1%, respectively. The highest rate of ICP (28.6%) was observed in women with high tHcy (> 15 μmol/L) and low PC (quartile 1); and the lowest rate of GDM (0.6%) was found in women with high tHcy and high PC (quartiles 2 to 4). In low PC group, the prevalence of ICP in women with high tHcy was significantly higher than that in women with low tHcy (≤ 15 μmol/L) (28.6% vs. 8.4%), representing an absolute risk increment of 20.2% and a relative risk increment of 3.3-fold (OR: 3.34; 95% CI: 1.55, 7.17; P = 0.002), whereas no joint effect was observed among high PC group. Conclusions Among Chinese pregnant women, one subgroup (high tHcy and low PC) has the highest risk of ICP and another (high tHcy and high PC) has the lowest risk of GDM; tHcy and platelet could be used as indicators to identify the women with high risk of ICP or low risk of GDM. |
| first_indexed | 2024-03-13T07:20:43Z |
| format | Article |
| id | doaj.art-eb53209e9a7743459330a83ca3ad4b3a |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-13T07:20:43Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj.art-eb53209e9a7743459330a83ca3ad4b3a2023-06-04T11:41:11ZengBMCBMC Public Health1471-24582023-06-0123111310.1186/s12889-023-16027-6Platelet counts affect the association between hyperhomocysteinemia and pregnancy complicationsBin Yu0Bin Zhang1Xiaoya Han2Wei Long3Wenbo Zhou4Xiaosong Yuan5Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical UniversityDepartment of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical UniversityDepartment of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical UniversityDepartment of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical UniversityDepartment of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical UniversityDepartment of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical UniversityAbstract Background The joint effect of platelet and other modifiers on the risk of pregnancy complications is unknown. This study investigated whether platelet count (PC) and total homocysteine (tHcy) level have a synergistic effect on the incidence of pregnancy complications in a Chinese population. Methods Total 11,553 consecutive pregnant women who received whole blood cell and biochemical tests at the time of admission for labor in Changzhou Maternal and Child Health Care Hospital were analyzed. The primary outcome was the prevalence of pregnancy complications: gestational diabetes mellitus (GDM), intrahepatic cholestasis of pregnancy (ICP), pre-eclampsia (PE), and pregnancy induced hypertension (PIH). Results The prevalence of GDM, ICP, PE, and PIH was 8.4%, 6.2%, 3.4%, and 2.1%, respectively. The highest rate of ICP (28.6%) was observed in women with high tHcy (> 15 μmol/L) and low PC (quartile 1); and the lowest rate of GDM (0.6%) was found in women with high tHcy and high PC (quartiles 2 to 4). In low PC group, the prevalence of ICP in women with high tHcy was significantly higher than that in women with low tHcy (≤ 15 μmol/L) (28.6% vs. 8.4%), representing an absolute risk increment of 20.2% and a relative risk increment of 3.3-fold (OR: 3.34; 95% CI: 1.55, 7.17; P = 0.002), whereas no joint effect was observed among high PC group. Conclusions Among Chinese pregnant women, one subgroup (high tHcy and low PC) has the highest risk of ICP and another (high tHcy and high PC) has the lowest risk of GDM; tHcy and platelet could be used as indicators to identify the women with high risk of ICP or low risk of GDM.https://doi.org/10.1186/s12889-023-16027-6HomocysteinePlateletPregnancy complicationsIntrahepatic cholestasis of pregnancyPregnant womenGestational diabetes mellitus |
| spellingShingle | Bin Yu Bin Zhang Xiaoya Han Wei Long Wenbo Zhou Xiaosong Yuan Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications BMC Public Health Homocysteine Platelet Pregnancy complications Intrahepatic cholestasis of pregnancy Pregnant women Gestational diabetes mellitus |
| title | Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications |
| title_full | Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications |
| title_fullStr | Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications |
| title_full_unstemmed | Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications |
| title_short | Platelet counts affect the association between hyperhomocysteinemia and pregnancy complications |
| title_sort | platelet counts affect the association between hyperhomocysteinemia and pregnancy complications |
| topic | Homocysteine Platelet Pregnancy complications Intrahepatic cholestasis of pregnancy Pregnant women Gestational diabetes mellitus |
| url | https://doi.org/10.1186/s12889-023-16027-6 |
| work_keys_str_mv | AT binyu plateletcountsaffecttheassociationbetweenhyperhomocysteinemiaandpregnancycomplications AT binzhang plateletcountsaffecttheassociationbetweenhyperhomocysteinemiaandpregnancycomplications AT xiaoyahan plateletcountsaffecttheassociationbetweenhyperhomocysteinemiaandpregnancycomplications AT weilong plateletcountsaffecttheassociationbetweenhyperhomocysteinemiaandpregnancycomplications AT wenbozhou plateletcountsaffecttheassociationbetweenhyperhomocysteinemiaandpregnancycomplications AT xiaosongyuan plateletcountsaffecttheassociationbetweenhyperhomocysteinemiaandpregnancycomplications |