SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination
Since the emergence of SARS-CoV-2, maintaining healthcare worker (HCW) health and safety has been fundamental to responding to the global pandemic. Vaccination with mRNA-base vaccines targeting SARS-CoV-2 spike protein has emerged as a key strategy in reducing HCW susceptibility to SARS-CoV-2, howev...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/2/358 |
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| author | Kevin D. Dieckhaus Min-Jung Kim Jian-Bing Shen Tina S. Liang Michael J. Kleinberg Kristen M. Siedlarz David B. Banach Mark L. Metersky Rob P. Fuller Eric M. Mortensen Bruce T. Liang |
| author_facet | Kevin D. Dieckhaus Min-Jung Kim Jian-Bing Shen Tina S. Liang Michael J. Kleinberg Kristen M. Siedlarz David B. Banach Mark L. Metersky Rob P. Fuller Eric M. Mortensen Bruce T. Liang |
| author_sort | Kevin D. Dieckhaus |
| collection | DOAJ |
| description | Since the emergence of SARS-CoV-2, maintaining healthcare worker (HCW) health and safety has been fundamental to responding to the global pandemic. Vaccination with mRNA-base vaccines targeting SARS-CoV-2 spike protein has emerged as a key strategy in reducing HCW susceptibility to SARS-CoV-2, however, neutralizing antibody responses subside with time and may be influenced by many variables. We sought to understand the dynamics between vaccine products, prior clinical illness from SARS-CoV-2, and incidence of vaccine-associated adverse reactions on antibody decay over time in HCWs at a university medical center. A cohort of 296 HCWs received standard two-dose vaccination with either bnt162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) and were evaluated after two, six, and nine months. Subjects were grouped by antibody decay curve into steep antibody decliners gentle decliners. Vaccination with mRNA-1273 led to more sustained antibody responses compared to bnt162b2. Subjects experiencing vaccine-associated symptoms were more likely to experience a more prolonged neutralizing antibody response. Subjects with clinical SARS-CoV-2 infection prior to vaccination were more likely to experience vaccination-associated symptoms after first vaccination and were more likely to have a more blunted antibody decay. Understanding factors associated with vaccine efficacy may assist clinicians in determining appropriate vaccine strategies in HCWs. |
| first_indexed | 2024-03-11T08:02:20Z |
| format | Article |
| id | doaj.art-eb538d69a54d440c8729eb13ef51cc37 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-11T08:02:20Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-eb538d69a54d440c8729eb13ef51cc372023-11-16T23:43:18ZengMDPI AGVaccines2076-393X2023-02-0111235810.3390/vaccines11020358SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA VaccinationKevin D. Dieckhaus0Min-Jung Kim1Jian-Bing Shen2Tina S. Liang3Michael J. Kleinberg4Kristen M. Siedlarz5David B. Banach6Mark L. Metersky7Rob P. Fuller8Eric M. Mortensen9Bruce T. Liang10UConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USAUConn Health, Farmington, CT 06030, USASince the emergence of SARS-CoV-2, maintaining healthcare worker (HCW) health and safety has been fundamental to responding to the global pandemic. Vaccination with mRNA-base vaccines targeting SARS-CoV-2 spike protein has emerged as a key strategy in reducing HCW susceptibility to SARS-CoV-2, however, neutralizing antibody responses subside with time and may be influenced by many variables. We sought to understand the dynamics between vaccine products, prior clinical illness from SARS-CoV-2, and incidence of vaccine-associated adverse reactions on antibody decay over time in HCWs at a university medical center. A cohort of 296 HCWs received standard two-dose vaccination with either bnt162b2 (Pfizer/BioNTech) or mRNA-1273 (Moderna) and were evaluated after two, six, and nine months. Subjects were grouped by antibody decay curve into steep antibody decliners gentle decliners. Vaccination with mRNA-1273 led to more sustained antibody responses compared to bnt162b2. Subjects experiencing vaccine-associated symptoms were more likely to experience a more prolonged neutralizing antibody response. Subjects with clinical SARS-CoV-2 infection prior to vaccination were more likely to experience vaccination-associated symptoms after first vaccination and were more likely to have a more blunted antibody decay. Understanding factors associated with vaccine efficacy may assist clinicians in determining appropriate vaccine strategies in HCWs.https://www.mdpi.com/2076-393X/11/2/358SARS-CoV-2COVID-19neutralizing antibodybnt162b2mRNA-1273healthcare workers |
| spellingShingle | Kevin D. Dieckhaus Min-Jung Kim Jian-Bing Shen Tina S. Liang Michael J. Kleinberg Kristen M. Siedlarz David B. Banach Mark L. Metersky Rob P. Fuller Eric M. Mortensen Bruce T. Liang SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination Vaccines SARS-CoV-2 COVID-19 neutralizing antibody bnt162b2 mRNA-1273 healthcare workers |
| title | SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination |
| title_full | SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination |
| title_fullStr | SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination |
| title_full_unstemmed | SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination |
| title_short | SARS-CoV-2 Antibody Dynamics in Healthcare Workers after mRNA Vaccination |
| title_sort | sars cov 2 antibody dynamics in healthcare workers after mrna vaccination |
| topic | SARS-CoV-2 COVID-19 neutralizing antibody bnt162b2 mRNA-1273 healthcare workers |
| url | https://www.mdpi.com/2076-393X/11/2/358 |
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