The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values
Background: The number of patients with breast cancer is increasing worldwide, resulting in a growing number of patients with chemotherapy-related cognitive impairment (CRCI), which seriously affects their quality of life. CRCI is associated with inflammatory factors and systemic inflammatory marker...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-11-01
|
| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354221140498 |
| _version_ | 1811307144500215808 |
|---|---|
| author | Senbang Yao MD Ke Ding MD Shaochun Liu MD Qianqian Zhang MD Wen Li MD Lingxue Tang MD Sheng Yu MD Lulian Pang MD Xiangxiang Yin MD Huaidong Cheng MD, PhD |
| author_facet | Senbang Yao MD Ke Ding MD Shaochun Liu MD Qianqian Zhang MD Wen Li MD Lingxue Tang MD Sheng Yu MD Lulian Pang MD Xiangxiang Yin MD Huaidong Cheng MD, PhD |
| author_sort | Senbang Yao MD |
| collection | DOAJ |
| description | Background: The number of patients with breast cancer is increasing worldwide, resulting in a growing number of patients with chemotherapy-related cognitive impairment (CRCI), which seriously affects their quality of life. CRCI is associated with inflammatory factors and systemic inflammatory markers such as pan-immune-inflammation value (PIV) and monocyte-to-lymphocyte ratio (MLR), which can reflect the level of inflammation in the body. While the Managing Cancer and Living Meaningfully (CALM) intervention has been demonstrated to alleviate CRCI in patients with breast cancer, the specific mechanism remains unclear. Objective: This study evaluated the impact of the CALM intervention on systemic inflammation. Methods: Ninety patients with breast cancer with CRCI were enrolled and randomized into care as usual (CAU) and CALM intervention groups. All patients were assessed using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), Mini-Mental State Exam (MMSE), and Functional Assessment of Cancer Therapy-Breast (FACT-B) before and after the CAU/CALM intervention. The blood levels of inflammatory markers were also analyzed before and after the intervention. Results: Compared to the CAU group, the CALM group showed significantly improved cognitive function and significantly decreased PIV ( P < .05). PIV was significantly negatively correlated with FACT-Cog ( P < .05). The levels of other inflammatory markers, including MLR, neutrophil-to-lymphocyte ratio (NLR), granulocyte-to-lymphocyte ratio (GLR), and systemic immune-inflammation index (SII), were also reduced in the CALM group. Conclusion: PIV is an important marker of inflammation. The CALM intervention may improve the cognitive function of patients by regulating the systemic inflammation marker PIV through the neuroimmune axis. |
| first_indexed | 2024-04-13T08:58:19Z |
| format | Article |
| id | doaj.art-eb53f6e02d524cc88af170d47a92fc99 |
| institution | Directory Open Access Journal |
| issn | 1552-695X |
| language | English |
| last_indexed | 2024-04-13T08:58:19Z |
| publishDate | 2022-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-eb53f6e02d524cc88af170d47a92fc992022-12-22T02:53:13ZengSAGE PublishingIntegrative Cancer Therapies1552-695X2022-11-012110.1177/15347354221140498The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation ValuesSenbang Yao MD0Ke Ding MD1Shaochun Liu MD2Qianqian Zhang MD3Wen Li MD4Lingxue Tang MD5Sheng Yu MD6Lulian Pang MD7Xiangxiang Yin MD8Huaidong Cheng MD, PhD9Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Radiation Oncology, Fuyang Cancer Hospital, Fuyang, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaBackground: The number of patients with breast cancer is increasing worldwide, resulting in a growing number of patients with chemotherapy-related cognitive impairment (CRCI), which seriously affects their quality of life. CRCI is associated with inflammatory factors and systemic inflammatory markers such as pan-immune-inflammation value (PIV) and monocyte-to-lymphocyte ratio (MLR), which can reflect the level of inflammation in the body. While the Managing Cancer and Living Meaningfully (CALM) intervention has been demonstrated to alleviate CRCI in patients with breast cancer, the specific mechanism remains unclear. Objective: This study evaluated the impact of the CALM intervention on systemic inflammation. Methods: Ninety patients with breast cancer with CRCI were enrolled and randomized into care as usual (CAU) and CALM intervention groups. All patients were assessed using the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog), Mini-Mental State Exam (MMSE), and Functional Assessment of Cancer Therapy-Breast (FACT-B) before and after the CAU/CALM intervention. The blood levels of inflammatory markers were also analyzed before and after the intervention. Results: Compared to the CAU group, the CALM group showed significantly improved cognitive function and significantly decreased PIV ( P < .05). PIV was significantly negatively correlated with FACT-Cog ( P < .05). The levels of other inflammatory markers, including MLR, neutrophil-to-lymphocyte ratio (NLR), granulocyte-to-lymphocyte ratio (GLR), and systemic immune-inflammation index (SII), were also reduced in the CALM group. Conclusion: PIV is an important marker of inflammation. The CALM intervention may improve the cognitive function of patients by regulating the systemic inflammation marker PIV through the neuroimmune axis.https://doi.org/10.1177/15347354221140498 |
| spellingShingle | Senbang Yao MD Ke Ding MD Shaochun Liu MD Qianqian Zhang MD Wen Li MD Lingxue Tang MD Sheng Yu MD Lulian Pang MD Xiangxiang Yin MD Huaidong Cheng MD, PhD The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values Integrative Cancer Therapies |
| title | The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values |
| title_full | The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values |
| title_fullStr | The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values |
| title_full_unstemmed | The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values |
| title_short | The Managing Cancer and Living Meaningfully (CALM) Intervention Alleviates Chemotherapy-Related Cognitive Impairment in Patients with Breast Cancer by Modulating Pan-Immune-Inflammation Values |
| title_sort | managing cancer and living meaningfully calm intervention alleviates chemotherapy related cognitive impairment in patients with breast cancer by modulating pan immune inflammation values |
| url | https://doi.org/10.1177/15347354221140498 |
| work_keys_str_mv | AT senbangyaomd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT kedingmd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT shaochunliumd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT qianqianzhangmd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT wenlimd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT lingxuetangmd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT shengyumd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT lulianpangmd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT xiangxiangyinmd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT huaidongchengmdphd themanagingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT senbangyaomd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT kedingmd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT shaochunliumd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT qianqianzhangmd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT wenlimd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT lingxuetangmd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT shengyumd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT lulianpangmd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT xiangxiangyinmd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues AT huaidongchengmdphd managingcancerandlivingmeaningfullycalminterventionalleviateschemotherapyrelatedcognitiveimpairmentinpatientswithbreastcancerbymodulatingpanimmuneinflammationvalues |