Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5
Protein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases. In this mini-review, we summarize and discuss relevant findings for the major birch and grass pollen allergens Bet v 1 and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Allergy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2023.1303943/full |
| _version_ | 1797404546255814656 |
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| author | Janine Fröhlich-Nowoisky Nadine Bothen Anna T. Backes Michael G. Weller Ulrich Pöschl |
| author_facet | Janine Fröhlich-Nowoisky Nadine Bothen Anna T. Backes Michael G. Weller Ulrich Pöschl |
| author_sort | Janine Fröhlich-Nowoisky |
| collection | DOAJ |
| description | Protein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases. In this mini-review, we summarize and discuss relevant findings for the major birch and grass pollen allergens Bet v 1 and Phl p 5 modified with tetranitromethane (laboratory studies), peroxynitrite (physiological processes), and ozone and nitrogen dioxide (environmental conditions). We focus on tyrosine nitration and the formation of protein dimers and higher oligomers via dityrosine cross-linking and the immunological effects studied. |
| first_indexed | 2024-03-09T02:56:34Z |
| format | Article |
| id | doaj.art-eb54eea9a9e742abad2c4742393462a6 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-03-09T02:56:34Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-eb54eea9a9e742abad2c4742393462a62023-12-05T04:42:16ZengFrontiers Media S.A.Frontiers in Allergy2673-61012023-12-01410.3389/falgy.2023.13039431303943Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5Janine Fröhlich-Nowoisky0Nadine Bothen1Anna T. Backes2Michael G. Weller3Ulrich Pöschl4Multiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, GermanyMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, GermanyMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, GermanyDivision 1.5 - Protein Analysis, Federal Institute for Materials Research and Testing (BAM), Berlin, GermanyMultiphase Chemistry Department, Max Planck Institute for Chemistry, Mainz, GermanyProtein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases. In this mini-review, we summarize and discuss relevant findings for the major birch and grass pollen allergens Bet v 1 and Phl p 5 modified with tetranitromethane (laboratory studies), peroxynitrite (physiological processes), and ozone and nitrogen dioxide (environmental conditions). We focus on tyrosine nitration and the formation of protein dimers and higher oligomers via dityrosine cross-linking and the immunological effects studied.https://www.frontiersin.org/articles/10.3389/falgy.2023.1303943/fullallergyBet v 1Phl p 5nitrationdimersoligomers |
| spellingShingle | Janine Fröhlich-Nowoisky Nadine Bothen Anna T. Backes Michael G. Weller Ulrich Pöschl Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5 Frontiers in Allergy allergy Bet v 1 Phl p 5 nitration dimers oligomers |
| title | Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5 |
| title_full | Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5 |
| title_fullStr | Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5 |
| title_full_unstemmed | Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5 |
| title_short | Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5 |
| title_sort | oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens bet v 1 and phl p 5 |
| topic | allergy Bet v 1 Phl p 5 nitration dimers oligomers |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2023.1303943/full |
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