Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis
The dynamic re-organization of cellular membranes in response to extracellular stimuli is fundamental to the cell physiology of myeloid and lymphoid cells of the immune system. In addition to maintaining cellular homeostatic functions, remodeling of the plasmalemma and endomembranes endow leukocytes...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-02-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.626136/full |
| _version_ | 1818617333981118464 |
|---|---|
| author | Fernando Montaño-Rendón Fernando Montaño-Rendón Sergio Grinstein Sergio Grinstein Sergio Grinstein Sergio Grinstein Glenn F. W. Walpole Glenn F. W. Walpole |
| author_facet | Fernando Montaño-Rendón Fernando Montaño-Rendón Sergio Grinstein Sergio Grinstein Sergio Grinstein Sergio Grinstein Glenn F. W. Walpole Glenn F. W. Walpole |
| author_sort | Fernando Montaño-Rendón |
| collection | DOAJ |
| description | The dynamic re-organization of cellular membranes in response to extracellular stimuli is fundamental to the cell physiology of myeloid and lymphoid cells of the immune system. In addition to maintaining cellular homeostatic functions, remodeling of the plasmalemma and endomembranes endow leukocytes with the potential to relay extracellular signals across their biological membranes to promote rolling adhesion and diapedesis, migration into the tissue parenchyma, and to ingest foreign particles and effete cells. Phosphoinositides, signaling lipids that control the interface of biological membranes with the external environment, are pivotal to this wealth of functions. Here, we highlight the complex metabolic transitions that occur to phosphoinositides during several stages of the leukocyte lifecycle, namely diapedesis, migration, and phagocytosis. We describe classical and recently developed tools that have aided our understanding of these complex lipids. Finally, major downstream effectors of inositides are highlighted including the cytoskeleton, emphasizing the importance of these rare lipids in immunity and disease. |
| first_indexed | 2024-12-16T17:04:02Z |
| format | Article |
| id | doaj.art-eb5816d9f36a435db0d7c559b582933d |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-16T17:04:02Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-eb5816d9f36a435db0d7c559b582933d2022-12-21T22:23:38ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-02-01910.3389/fcell.2021.626136626136Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and PhagocytosisFernando Montaño-Rendón0Fernando Montaño-Rendón1Sergio Grinstein2Sergio Grinstein3Sergio Grinstein4Sergio Grinstein5Glenn F. W. Walpole6Glenn F. W. Walpole7Program in Cell Biology, Hospital for Sick Children, Toronto, ON, CanadaInstitute of Medical Sciences, University of Toronto, Toronto, ON, CanadaProgram in Cell Biology, Hospital for Sick Children, Toronto, ON, CanadaInstitute of Medical Sciences, University of Toronto, Toronto, ON, CanadaDepartment of Biochemistry, University of Toronto, Toronto, ON, CanadaKeenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, CanadaProgram in Cell Biology, Hospital for Sick Children, Toronto, ON, CanadaDepartment of Biochemistry, University of Toronto, Toronto, ON, CanadaThe dynamic re-organization of cellular membranes in response to extracellular stimuli is fundamental to the cell physiology of myeloid and lymphoid cells of the immune system. In addition to maintaining cellular homeostatic functions, remodeling of the plasmalemma and endomembranes endow leukocytes with the potential to relay extracellular signals across their biological membranes to promote rolling adhesion and diapedesis, migration into the tissue parenchyma, and to ingest foreign particles and effete cells. Phosphoinositides, signaling lipids that control the interface of biological membranes with the external environment, are pivotal to this wealth of functions. Here, we highlight the complex metabolic transitions that occur to phosphoinositides during several stages of the leukocyte lifecycle, namely diapedesis, migration, and phagocytosis. We describe classical and recently developed tools that have aided our understanding of these complex lipids. Finally, major downstream effectors of inositides are highlighted including the cytoskeleton, emphasizing the importance of these rare lipids in immunity and disease.https://www.frontiersin.org/articles/10.3389/fcell.2021.626136/fullphosphoinositidesinositol lipidsmacrophageneutrophilchemotaxisphagocytosis |
| spellingShingle | Fernando Montaño-Rendón Fernando Montaño-Rendón Sergio Grinstein Sergio Grinstein Sergio Grinstein Sergio Grinstein Glenn F. W. Walpole Glenn F. W. Walpole Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis Frontiers in Cell and Developmental Biology phosphoinositides inositol lipids macrophage neutrophil chemotaxis phagocytosis |
| title | Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis |
| title_full | Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis |
| title_fullStr | Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis |
| title_full_unstemmed | Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis |
| title_short | Monitoring Phosphoinositide Fluxes and Effectors During Leukocyte Chemotaxis and Phagocytosis |
| title_sort | monitoring phosphoinositide fluxes and effectors during leukocyte chemotaxis and phagocytosis |
| topic | phosphoinositides inositol lipids macrophage neutrophil chemotaxis phagocytosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.626136/full |
| work_keys_str_mv | AT fernandomontanorendon monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis AT fernandomontanorendon monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis AT sergiogrinstein monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis AT sergiogrinstein monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis AT sergiogrinstein monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis AT sergiogrinstein monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis AT glennfwwalpole monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis AT glennfwwalpole monitoringphosphoinositidefluxesandeffectorsduringleukocytechemotaxisandphagocytosis |