Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study
Data concerning metabolic consequences in women with polycystic ovary syndrome (PCOS) are delivered mainly by cross-sectional studies. In this research, we re-examined 31 Caucasian PCOS women after a median period of 120.9 months to evaluate the changes in metabolic syndrome components. Clinical exa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/10/3367 |
| _version_ | 1797550355586744320 |
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| author | Małgorzata Jacewicz-Święcka Irina Kowalska |
| author_facet | Małgorzata Jacewicz-Święcka Irina Kowalska |
| author_sort | Małgorzata Jacewicz-Święcka |
| collection | DOAJ |
| description | Data concerning metabolic consequences in women with polycystic ovary syndrome (PCOS) are delivered mainly by cross-sectional studies. In this research, we re-examined 31 Caucasian PCOS women after a median period of 120.9 months to evaluate the changes in metabolic syndrome components. Clinical examination, oral glucose tolerance test with estimations of glucose and insulin, lipids, sex hormone-binding globulin (SHBG<strong>)</strong> and sex hormones assessments were performed on two occasions. Additionally, the euglycaemic hyperinsulinaemic clamp technique was used at the baseline to assess insulin sensitivity (M-clamp value). In the end, the median age of participants was 35. We observed an increase in glucose concentrations, a decrease in insulin concentrations and no changes in insulin resistance markers. Final mean glucose, mean insulin, Matsuda index and body mass index (BMI) were correlated with baseline M-clamp value and SHBG (<em>p </em>< 0.01). During the follow-up, no one in the sample developed diabetes. The annualised incidence rate for conversion from normoglycaemia to prediabetes totalled 4.5%. Baseline BMI, free androgen index, fasting glucose and M-clamp value were identified as prediabetes predictors in young PCOS women (respectively, OR = 1.17, OR = 1.42, OR = 1.2, OR = 0.73, <em>p </em>< 0.05). Prediabetes appeared in 76.47% of the women with a final BMI of ≥ 25 kg/m<sup>2</sup> and in 7.14% of the normal-weight women (<em>p </em>= 0.0001). In conclusion, we report a high rate of adverse change in glucose metabolism in overweight and obese participants, a deterioration in β-cell function and strong correlations between metabolic parameters assessed in the third and the fourth decade in PCOS women, emphasising the role of early intervention to prevent cardiometabolic diseases. |
| first_indexed | 2024-03-10T15:28:02Z |
| format | Article |
| id | doaj.art-eb58660112024af3bbf122e237dc732b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T15:28:02Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-eb58660112024af3bbf122e237dc732b2023-11-20T17:52:40ZengMDPI AGJournal of Clinical Medicine2077-03832020-10-01910336710.3390/jcm9103367Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up StudyMałgorzata Jacewicz-Święcka0Irina Kowalska1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, 15-089 Białystok, PolandDepartment of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, 15-089 Białystok, PolandData concerning metabolic consequences in women with polycystic ovary syndrome (PCOS) are delivered mainly by cross-sectional studies. In this research, we re-examined 31 Caucasian PCOS women after a median period of 120.9 months to evaluate the changes in metabolic syndrome components. Clinical examination, oral glucose tolerance test with estimations of glucose and insulin, lipids, sex hormone-binding globulin (SHBG<strong>)</strong> and sex hormones assessments were performed on two occasions. Additionally, the euglycaemic hyperinsulinaemic clamp technique was used at the baseline to assess insulin sensitivity (M-clamp value). In the end, the median age of participants was 35. We observed an increase in glucose concentrations, a decrease in insulin concentrations and no changes in insulin resistance markers. Final mean glucose, mean insulin, Matsuda index and body mass index (BMI) were correlated with baseline M-clamp value and SHBG (<em>p </em>< 0.01). During the follow-up, no one in the sample developed diabetes. The annualised incidence rate for conversion from normoglycaemia to prediabetes totalled 4.5%. Baseline BMI, free androgen index, fasting glucose and M-clamp value were identified as prediabetes predictors in young PCOS women (respectively, OR = 1.17, OR = 1.42, OR = 1.2, OR = 0.73, <em>p </em>< 0.05). Prediabetes appeared in 76.47% of the women with a final BMI of ≥ 25 kg/m<sup>2</sup> and in 7.14% of the normal-weight women (<em>p </em>= 0.0001). In conclusion, we report a high rate of adverse change in glucose metabolism in overweight and obese participants, a deterioration in β-cell function and strong correlations between metabolic parameters assessed in the third and the fourth decade in PCOS women, emphasising the role of early intervention to prevent cardiometabolic diseases.https://www.mdpi.com/2077-0383/9/10/3367PCOSprediabetesinsulin resistancemetabolic syndromelongitudinal study |
| spellingShingle | Małgorzata Jacewicz-Święcka Irina Kowalska Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study Journal of Clinical Medicine PCOS prediabetes insulin resistance metabolic syndrome longitudinal study |
| title | Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study |
| title_full | Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study |
| title_fullStr | Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study |
| title_full_unstemmed | Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study |
| title_short | Changes in Metabolic Profile in the Women with a History of PCOS—A Long-Term Follow-Up Study |
| title_sort | changes in metabolic profile in the women with a history of pcos a long term follow up study |
| topic | PCOS prediabetes insulin resistance metabolic syndrome longitudinal study |
| url | https://www.mdpi.com/2077-0383/9/10/3367 |
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