AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES
<p>The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing c...
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| Format: | Article |
| Language: | English |
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El Oued University
2016-01-01
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| Series: | Journal of Fundamental and Applied Sciences |
| Subjects: | |
| Online Access: | http://jfas.info/index.php/jfas/article/view/50 |
| _version_ | 1817975682183987200 |
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| author | P. S. Manjula B. K. Sarojini B. Narayana C. G. Darshan Raj |
| author_facet | P. S. Manjula B. K. Sarojini B. Narayana C. G. Darshan Raj |
| author_sort | P. S. Manjula |
| collection | DOAJ |
| description | <p>The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing compounds, such as natural products and medicinally relevant compounds. The versatility and potential of these compounds to introduce both functional and structural diversity using the Mannich reaction have stimulated the creativity of chemists. Keeping in view of the importance of this organic moiety in the field of medicine and biology here an attempt has been made to review the synthesis and biological importance of heterocyclic Mannich base derivatives.</p> |
| first_indexed | 2024-04-13T21:53:10Z |
| format | Article |
| id | doaj.art-eb589e22d61645a48a50ae0168d5b86e |
| institution | Directory Open Access Journal |
| issn | 1112-9867 |
| language | English |
| last_indexed | 2024-04-13T21:53:10Z |
| publishDate | 2016-01-01 |
| publisher | El Oued University |
| record_format | Article |
| series | Journal of Fundamental and Applied Sciences |
| spelling | doaj.art-eb589e22d61645a48a50ae0168d5b86e2022-12-22T02:28:22ZengEl Oued UniversityJournal of Fundamental and Applied Sciences1112-98672016-01-018111517510.4314/jfas.v8i1.9168AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASESP. S. ManjulaB. K. SarojiniB. NarayanaC. G. Darshan Raj<p>The Mannich reaction is a three-component reaction of an aldehyde, a primary or secondary amine and a ketone which is one of the most powerful C-C bond forming reactions in organic synthesis. It leads to β-amino carbonyl compounds, which are useful for the syntheses of nitrogen containing compounds, such as natural products and medicinally relevant compounds. The versatility and potential of these compounds to introduce both functional and structural diversity using the Mannich reaction have stimulated the creativity of chemists. Keeping in view of the importance of this organic moiety in the field of medicine and biology here an attempt has been made to review the synthesis and biological importance of heterocyclic Mannich base derivatives.</p>http://jfas.info/index.php/jfas/article/view/50Amines, β-amino carbonyl compounds, Biological activity, Heterocyclic Mannich base derivative, Ketones, Mannich reaction |
| spellingShingle | P. S. Manjula B. K. Sarojini B. Narayana C. G. Darshan Raj AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES Journal of Fundamental and Applied Sciences Amines, β-amino carbonyl compounds, Biological activity, Heterocyclic Mannich base derivative, Ketones, Mannich reaction |
| title | AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES |
| title_full | AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES |
| title_fullStr | AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES |
| title_full_unstemmed | AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES |
| title_short | AN EXPLORATION ON THE SYNTHESIS AND BIO-APPLICATIONS OF DERIVATIVES OF HETEROCYCLIC MANNICH BASES |
| title_sort | exploration on the synthesis and bio applications of derivatives of heterocyclic mannich bases |
| topic | Amines, β-amino carbonyl compounds, Biological activity, Heterocyclic Mannich base derivative, Ketones, Mannich reaction |
| url | http://jfas.info/index.php/jfas/article/view/50 |
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