WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP

WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP

WP1130, a partially selective deubiquitinases (DUB) inhibitor, inhibits the deubiquitinating activities of USP5, USP9X, USP14, USP37, and UCHL1. In this study, we investigate whether WP1130 exerts sensitizing effect on TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human renal ca...

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Bibliographic Details
Main Authors: Seok Kim, Seon Min Woo, Kyoung-jin Min, Seung Un Seo, Tae-Jin Lee, Peter Kubatka, Dong Eun Kim, Taeg Kyu Kwon
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
WP1130
TRAIL
c-FLIP
DR5
MicroRNA
Online Access:http://www.mdpi.com/2072-6694/11/3/344

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