Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients
The glutamatergic system has previously been shown to be involved in the pathophysiology of schizophrenia and the mechanisms of action of antipsychotic treatment. The present study aimed to investigate the relationship between the levels of glutamate (Glu) or Glu/total creatine (Glu/Cr+PCr) in the a...
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.553269/full |
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| author | Jinguang Li Jinguang Li Honghong Ren Ying He ZongChang Li Xiaoqian Ma Liu Yuan Lijun Ouyang Jun Zhou Dong Wang Chunwang Li Xiaogang Chen Hongying Han Jinsong Tang Jinsong Tang |
| author_facet | Jinguang Li Jinguang Li Honghong Ren Ying He ZongChang Li Xiaoqian Ma Liu Yuan Lijun Ouyang Jun Zhou Dong Wang Chunwang Li Xiaogang Chen Hongying Han Jinsong Tang Jinsong Tang |
| author_sort | Jinguang Li |
| collection | DOAJ |
| description | The glutamatergic system has previously been shown to be involved in the pathophysiology of schizophrenia and the mechanisms of action of antipsychotic treatment. The present study aimed to investigate the relationship between the levels of glutamate (Glu) or Glu/total creatine (Glu/Cr+PCr) in the anterior cingulate cortex (ACC) and psychiatric symptoms as well as the response to antipsychotic treatment. We performed proton magnetic resonance spectroscopy (1H–MRS) to measure Glu and Glu/Cr+PCr in the ACC of 35 drug-naïve first-episode schizophrenia (FES) patients and 40 well-matched healthy controls (HCs). After scanning, we treated the patients with risperidone for eight weeks. Remission status was based on the Positive and Negative Syndrome Scale (PANSS) scores at week 8. At baseline, there were no significant differences in the levels of Glu or Glu/Cr+PCr in the ACC between drug-naïve FES patients and HCs. Lower baseline levels of Glu/Cr+PCr but not Glu in the ACC were associated with more severe negative symptoms of schizophrenia. Compared to the remission group (RM), the non-remission group (NRM) had lower baseline ACC Glu levels (P < 0.05). Our results suggest that ACC Glu levels may be related to the severity of symptoms in the early stages of schizophrenia and therefore may be a marker with which to evaluate the treatment effect of antipsychotics in schizophrenia patients. |
| first_indexed | 2024-12-11T19:59:31Z |
| format | Article |
| id | doaj.art-eb594fc8a4404e06a7715397e2e1803a |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T19:59:31Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-eb594fc8a4404e06a7715397e2e1803a2022-12-22T00:52:33ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-10-011110.3389/fpsyt.2020.553269553269Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia PatientsJinguang Li0Jinguang Li1Honghong Ren2Ying He3ZongChang Li4Xiaoqian Ma5Liu Yuan6Lijun Ouyang7Jun Zhou8Dong Wang9Chunwang Li10Xiaogang Chen11Hongying Han12Jinsong Tang13Jinsong Tang14Hunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaAffiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, ChinaDepartment of Radiology, Hunan Childen's Hospital, Changsha, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaHunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, National Clinical Research Center for Mental Disorders, Hunan Medical Center for Mental Health, China National Technology Institute on Mental Disorders, Institute of Mental Health, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaThe glutamatergic system has previously been shown to be involved in the pathophysiology of schizophrenia and the mechanisms of action of antipsychotic treatment. The present study aimed to investigate the relationship between the levels of glutamate (Glu) or Glu/total creatine (Glu/Cr+PCr) in the anterior cingulate cortex (ACC) and psychiatric symptoms as well as the response to antipsychotic treatment. We performed proton magnetic resonance spectroscopy (1H–MRS) to measure Glu and Glu/Cr+PCr in the ACC of 35 drug-naïve first-episode schizophrenia (FES) patients and 40 well-matched healthy controls (HCs). After scanning, we treated the patients with risperidone for eight weeks. Remission status was based on the Positive and Negative Syndrome Scale (PANSS) scores at week 8. At baseline, there were no significant differences in the levels of Glu or Glu/Cr+PCr in the ACC between drug-naïve FES patients and HCs. Lower baseline levels of Glu/Cr+PCr but not Glu in the ACC were associated with more severe negative symptoms of schizophrenia. Compared to the remission group (RM), the non-remission group (NRM) had lower baseline ACC Glu levels (P < 0.05). Our results suggest that ACC Glu levels may be related to the severity of symptoms in the early stages of schizophrenia and therefore may be a marker with which to evaluate the treatment effect of antipsychotics in schizophrenia patients.https://www.frontiersin.org/articles/10.3389/fpsyt.2020.553269/fullglutamatemagnetic resonance spectroscopyACCanterior cingulate cortexCrcreatine |
| spellingShingle | Jinguang Li Jinguang Li Honghong Ren Ying He ZongChang Li Xiaoqian Ma Liu Yuan Lijun Ouyang Jun Zhou Dong Wang Chunwang Li Xiaogang Chen Hongying Han Jinsong Tang Jinsong Tang Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients Frontiers in Psychiatry glutamate magnetic resonance spectroscopy ACC anterior cingulate cortex Cr creatine |
| title | Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients |
| title_full | Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients |
| title_fullStr | Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients |
| title_full_unstemmed | Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients |
| title_short | Anterior Cingulate Cortex Glutamate Levels Are Related to Response to Initial Antipsychotic Treatment in Drug-Naive First-Episode Schizophrenia Patients |
| title_sort | anterior cingulate cortex glutamate levels are related to response to initial antipsychotic treatment in drug naive first episode schizophrenia patients |
| topic | glutamate magnetic resonance spectroscopy ACC anterior cingulate cortex Cr creatine |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.553269/full |
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