Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity

Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity

Uridine-diphosphate (UDP) and its receptor P2Y6 have recently been identified as regulators of AgRP neurons. UDP promotes feeding via activation of P2Y6 receptors on AgRP neurons, and hypothalamic UDP concentrations are increased in obesity. However, it remained unresolved whether inhibition of P2Y6...

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Bibliographic Details
Main Authors: Sophie Marie Steculorum, Katharina Timper, Linda Engström Ruud, Nadine Evers, Lars Paeger, Stephan Bremser, Peter Kloppenburg, Jens Claus Brüning
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
obesity
insulin sensitivity
AgRP neurons
P2Y6
diabetes
food intake
hypothalamus
arcuate nucleus
insulin resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471730102X

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http://www.sciencedirect.com/science/article/pii/S221112471730102X

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