Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code
Aminoacyl-tRNA synthetases use a variety of mechanisms to ensure fidelity of the genetic code and ultimately select the correct amino acids to be used in protein synthesis. The physiological necessity of these quality control mechanisms in different environments remains unclear, as the cost vs benef...
Main Authors: | Tammy J Bullwinkle, Noah M Reynolds, Medha Raina, Adil Moghal, Eleftheria Matsa, Andrei Rajkovic, Huseyin Kayadibi, Farbod Fazlollahi, Christopher Ryan, Nathaniel Howitz, Kym F Faull, Beth A Lazazzera, Michael Ibba |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-06-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/02501 |
Similar Items
-
Mistranslating the genetic code with leucine in yeast and mammalian cells
by: Josephine Davey-Young, et al.
Published: (2024-12-01) -
Genomic innovation of ATD alleviates mistranslation associated with multicellularity in Animalia
by: Santosh Kumar Kuncha, et al.
Published: (2020-05-01) -
Misunderstanding and mistranslation in the origins of the Pacific War of 1941-1945 : the importance of magic
by: Komatsu, K
Published: (1994) -
The Global Consequences of Mistranslation: The Adoption of the “Black but …” Formulation in Europe, 1440–1650
by: Kate Lowe
Published: (2012-06-01) -
tRNAs as regulators of biological processes
by: Medha eRaina, et al.
Published: (2014-06-01)