Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives
Twelve novel triazolothiadiazole derivatives were synthesized from 4-amino-5-substituted-4H-1,2,4-triazole-3-thiols with various aromatic carboxylic acids by cyclization in the presence of phosphorous oxychloride. All the newly synthesized compounds were characterized by FTIR, 1H NMR, mass spectrosc...
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| Format: | Article |
| Language: | English |
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Chemical Society of Ethiopia
2018-01-01
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| Series: | Bulletin of the Chemical Society of Ethiopia |
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| Online Access: | https://www.ajol.info/index.php/bcse/article/view/165356 |
| _version_ | 1811276361907568640 |
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| author | L. Lin, H. Liu D. J. Wang Y. J. Hu X. H. Wei |
| author_facet | L. Lin, H. Liu D. J. Wang Y. J. Hu X. H. Wei |
| author_sort | L. Lin, |
| collection | DOAJ |
| description | Twelve novel triazolothiadiazole derivatives were synthesized from 4-amino-5-substituted-4H-1,2,4-triazole-3-thiols with various aromatic carboxylic acids by cyclization in the presence of phosphorous oxychloride. All the newly synthesized compounds were characterized by FTIR, 1H NMR, mass spectroscopy and elemental analysis. The antimicrobial activities of the title compounds were examined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. The bioassay indicated all synthesized triazolothiadiazole derivatives possessed moderate to good antibacterial and antifungal activities against the tested organisms. Especially, compounds 2e and 2k exhibited excellent antibacterial and antifungal activities among these triazolothiadiazole derivatives. |
| first_indexed | 2024-04-12T23:55:14Z |
| format | Article |
| id | doaj.art-eb5b9288d700485c9fba8b2f37852d2e |
| institution | Directory Open Access Journal |
| issn | 1011-3924 1726-801X |
| language | English |
| last_indexed | 2024-04-12T23:55:14Z |
| publishDate | 2018-01-01 |
| publisher | Chemical Society of Ethiopia |
| record_format | Article |
| series | Bulletin of the Chemical Society of Ethiopia |
| spelling | doaj.art-eb5b9288d700485c9fba8b2f37852d2e2022-12-22T03:11:33ZengChemical Society of EthiopiaBulletin of the Chemical Society of Ethiopia1011-39241726-801X2018-01-01313481489http://dx.doi.org/10.4314/bcse.v31i3.12Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivativesL. Lin, H. LiuD. J. WangY. J. HuX. H. WeiTwelve novel triazolothiadiazole derivatives were synthesized from 4-amino-5-substituted-4H-1,2,4-triazole-3-thiols with various aromatic carboxylic acids by cyclization in the presence of phosphorous oxychloride. All the newly synthesized compounds were characterized by FTIR, 1H NMR, mass spectroscopy and elemental analysis. The antimicrobial activities of the title compounds were examined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. The bioassay indicated all synthesized triazolothiadiazole derivatives possessed moderate to good antibacterial and antifungal activities against the tested organisms. Especially, compounds 2e and 2k exhibited excellent antibacterial and antifungal activities among these triazolothiadiazole derivatives.https://www.ajol.info/index.php/bcse/article/view/165356TriazolothiadiazoleTriazoleThiadiazoleAntimicrobial activity |
| spellingShingle | L. Lin, H. Liu D. J. Wang Y. J. Hu X. H. Wei Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives Bulletin of the Chemical Society of Ethiopia Triazolothiadiazole Triazole Thiadiazole Antimicrobial activity |
| title | Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives |
| title_full | Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives |
| title_fullStr | Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives |
| title_full_unstemmed | Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives |
| title_short | Synthesis and biological activities of 3,6-disubstituted-1,2,4-triazolo-1,3,4- thiadiazole derivatives |
| title_sort | synthesis and biological activities of 3 6 disubstituted 1 2 4 triazolo 1 3 4 thiadiazole derivatives |
| topic | Triazolothiadiazole Triazole Thiadiazole Antimicrobial activity |
| url | https://www.ajol.info/index.php/bcse/article/view/165356 |
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