Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation.
Antibodies named TcCRA "Trypanosoma cruzi Cross Reactive Antibodies" were detected in 47% of blood donors from French population unexposed to the parasite. In order to evaluate the passive or active transmissibility of TcCRA and further characterize its role and etiology, we have conducted...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4564178?pdf=render |
| _version_ | 1811338229337554944 |
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| author | Esber S Saba Lucie Gueyffier Marie-Laure Danjoy Philippe Vanhems Bruno Pozzetto Mohamad Sobh Hans Pottel Mauricette Michallet Maan A Zrein |
| author_facet | Esber S Saba Lucie Gueyffier Marie-Laure Danjoy Philippe Vanhems Bruno Pozzetto Mohamad Sobh Hans Pottel Mauricette Michallet Maan A Zrein |
| author_sort | Esber S Saba |
| collection | DOAJ |
| description | Antibodies named TcCRA "Trypanosoma cruzi Cross Reactive Antibodies" were detected in 47% of blood donors from French population unexposed to the parasite. In order to evaluate the passive or active transmissibility of TcCRA and further characterize its role and etiology, we have conducted a study in a cohort of 47 patients who underwent allogeneic Hematopoietic Stem Cell Transplantations (allo-HSCT). Donors and recipients were tested for TcCRA prior to transplantation. Recipients were further tested during follow-up after transplantation. Demographical, clinical and biological data were collected. Our primary end-point was to assess the risk of TcCRA acquisition after transplantation. During this initial analysis, we observed no seroconversion in patients receiving cells from TcCRA negative donors (n = 23) but detected seroconversion in 4 out of 24 patients who received hematopoietic stem cells from positive donors. Here, we are discussing possible scenarios to explain TcCRA-immune status in recipient after transplantation. |
| first_indexed | 2024-04-13T18:07:48Z |
| format | Article |
| id | doaj.art-eb5d06a926664601b71fe97c889dfa12 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T18:07:48Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eb5d06a926664601b71fe97c889dfa122022-12-22T02:36:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01109e013724010.1371/journal.pone.0137240Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation.Esber S SabaLucie GueyffierMarie-Laure DanjoyPhilippe VanhemsBruno PozzettoMohamad SobhHans PottelMauricette MichalletMaan A ZreinAntibodies named TcCRA "Trypanosoma cruzi Cross Reactive Antibodies" were detected in 47% of blood donors from French population unexposed to the parasite. In order to evaluate the passive or active transmissibility of TcCRA and further characterize its role and etiology, we have conducted a study in a cohort of 47 patients who underwent allogeneic Hematopoietic Stem Cell Transplantations (allo-HSCT). Donors and recipients were tested for TcCRA prior to transplantation. Recipients were further tested during follow-up after transplantation. Demographical, clinical and biological data were collected. Our primary end-point was to assess the risk of TcCRA acquisition after transplantation. During this initial analysis, we observed no seroconversion in patients receiving cells from TcCRA negative donors (n = 23) but detected seroconversion in 4 out of 24 patients who received hematopoietic stem cells from positive donors. Here, we are discussing possible scenarios to explain TcCRA-immune status in recipient after transplantation.http://europepmc.org/articles/PMC4564178?pdf=render |
| spellingShingle | Esber S Saba Lucie Gueyffier Marie-Laure Danjoy Philippe Vanhems Bruno Pozzetto Mohamad Sobh Hans Pottel Mauricette Michallet Maan A Zrein Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation. PLoS ONE |
| title | Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation. |
| title_full | Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation. |
| title_fullStr | Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation. |
| title_full_unstemmed | Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation. |
| title_short | Trypanosoma-Cruzi Cross-Reactive Antibodies Longitudinal Follow-Up: A Prospective Observational Study in Hematopoietic Stem Cell Transplantation. |
| title_sort | trypanosoma cruzi cross reactive antibodies longitudinal follow up a prospective observational study in hematopoietic stem cell transplantation |
| url | http://europepmc.org/articles/PMC4564178?pdf=render |
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