SARS-CoV-2 RBD trimer protein adjuvanted with Alum-3M-052 protects from SARS-CoV-2 infection and immune pathology in the lung
Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.
Bibliographic Details
| Main Authors: |
Nanda Kishore Routhu,
Narayanaiah Cheedarla,
Venkata Satish Bollimpelli,
Sailaja Gangadhara,
Venkata Viswanadh Edara,
Lilin Lai,
Anusmita Sahoo,
Ayalnesh Shiferaw,
Tiffany M. Styles,
Katharine Floyd,
Stephanie Fischinger,
Caroline Atyeo,
Sally A. Shin,
Sanjeev Gumber,
Shannon Kirejczyk,
Kenneth H. Dinnon,
Pei-Yong Shi,
Vineet D. Menachery,
Mark Tomai,
Christopher B. Fox,
Galit Alter,
Thomas H. Vanderford,
Lisa Gralinski,
Mehul S. Suthar,
Rama Rao Amara |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-23942-y
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