GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

GSDMD-mediated pyroptosis restrains intracellular Chlamydia trachomatis growth in macrophages

Pyroptosis, a type of programmed necrosis associated with inflammatory, is a host defense mechanism against microbial infections. Although Chlamydia has been shown to induce pyroptosis, whether pyroptosis directly impacts the growth of Chlamydia has not been demonstrated. In this study, we found tha...

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Bibliographic Details
Main Authors: Ping Jiang, Hongzhi Chen, Xiaojing Feng, Huiqi Xie, Mengjie Jiang, Danning Xu, Haoneng Tang, Ningjie Zhang, Jianlin Chen, Lei Zhang, Lingli Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Chlamydia trachomatis
GSDMD
pyroptosis
macrophage
caspase-1
caspase-11
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1116335/full

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