Growth Factor Mediated Signaling in Pancreatic Pathogenesis
Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-02-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/3/1/841/ |
| _version_ | 1797728376955338752 |
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| author | Debashis Nandy Debabrata Mukhopadhyay |
| author_facet | Debashis Nandy Debabrata Mukhopadhyay |
| author_sort | Debashis Nandy |
| collection | DOAJ |
| description | Functionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed. |
| first_indexed | 2024-03-12T11:13:05Z |
| format | Article |
| id | doaj.art-eb613ed46abe405c99ea34a2be0c3e97 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T11:13:05Z |
| publishDate | 2011-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-eb613ed46abe405c99ea34a2be0c3e972023-09-02T02:30:40ZengMDPI AGCancers2072-66942011-02-013184187110.3390/cancers3010841Growth Factor Mediated Signaling in Pancreatic PathogenesisDebashis NandyDebabrata MukhopadhyayFunctionally, the pancreas consists of two types of tissues: exocrine and endocrine. Exocrine pancreatic disorders mainly involve acute and chronic pancreatitis. Acute pancreatitis typically is benign, while chronic pancreatitis is considered a risk factor for developing pancreatic cancer. Pancreatic carcinoma is the fourth leading cause of cancer related deaths worldwide. Most pancreatic cancers develop in the exocrine tissues. Endocrine pancreatic tumors are more uncommon, and typically are less aggressive than exocrine tumors. However, the endocrine pancreatic disorder, diabetes, is a dominant cause of morbidity and mortality. Importantly, different growth factors and their receptors play critical roles in pancreatic pathogenesis. Hence, an improved understanding of how various growth factors affect pancreatitis and pancreatic carcinoma is necessary to determine appropriate treatment. This chapter describes the role of different growth factors such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and transforming growth factor (TGF) in various pancreatic pathophysiologies. Finally, the crosstalk between different growth factor axes and their respective signaling mechanisms, which are involved in pancreatitis and pancreatic carcinoma, are also discussed.http://www.mdpi.com/2072-6694/3/1/841/growth factorssignalingpancreatitispancreatic carcinoma |
| spellingShingle | Debashis Nandy Debabrata Mukhopadhyay Growth Factor Mediated Signaling in Pancreatic Pathogenesis Cancers growth factors signaling pancreatitis pancreatic carcinoma |
| title | Growth Factor Mediated Signaling in Pancreatic Pathogenesis |
| title_full | Growth Factor Mediated Signaling in Pancreatic Pathogenesis |
| title_fullStr | Growth Factor Mediated Signaling in Pancreatic Pathogenesis |
| title_full_unstemmed | Growth Factor Mediated Signaling in Pancreatic Pathogenesis |
| title_short | Growth Factor Mediated Signaling in Pancreatic Pathogenesis |
| title_sort | growth factor mediated signaling in pancreatic pathogenesis |
| topic | growth factors signaling pancreatitis pancreatic carcinoma |
| url | http://www.mdpi.com/2072-6694/3/1/841/ |
| work_keys_str_mv | AT debashisnandy growthfactormediatedsignalinginpancreaticpathogenesis AT debabratamukhopadhyay growthfactormediatedsignalinginpancreaticpathogenesis |