Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age
Long-term survival for acute lymphoblastic leukemia (ALL) in children improved over the last three decades up to 80-90% of affected patients. Consequently, the quality of life of survivors has become increasingly important. This study analyses the clinical features and outcome of 119 children with A...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Hematology Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/8847 |
| _version_ | 1797935718948929536 |
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| author | Lara Devilli Chiara Garonzi Rita Balter Elisa Bonetti Matteo Chinello Ada Zaccaron Virginia Vitale Massimiliano De Bortoli Giulia Caddeo Valentina Baretta Gloria Tridello Simone Cesaro |
| author_facet | Lara Devilli Chiara Garonzi Rita Balter Elisa Bonetti Matteo Chinello Ada Zaccaron Virginia Vitale Massimiliano De Bortoli Giulia Caddeo Valentina Baretta Gloria Tridello Simone Cesaro |
| author_sort | Lara Devilli |
| collection | DOAJ |
| description | Long-term survival for acute lymphoblastic leukemia (ALL) in children improved over the last three decades up to 80-90% of affected patients. Consequently, the quality of life of survivors has become increasingly important. This study analyses the clinical features and outcome of 119 children with ALL, focusing on the quality of long-term survival in a subset of 22 patients over 18 years of age. Among this group, the 10-year event-free survival and overall survival were 83.1% (C.I. 74.0-89.2) and 88.4% (C.I. 80.9-93.1), respectively. Treatment related long-term medical complications were reported only in 2 patients (9.1%). Secondary school was completed successfully in 20 of 22 patients (89.9%). The remaining 2 patients were still attending at the time of the analysis. In conclusion, current treatment for ALL is well tolerated and does not compromise significantly the quality of life of survivors. |
| first_indexed | 2024-04-10T18:18:32Z |
| format | Article |
| id | doaj.art-eb66522ef8e247deb2bbc6600a4e4aaa |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:18:32Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-eb66522ef8e247deb2bbc6600a4e4aaa2023-02-02T08:06:43ZengMDPI AGHematology Reports2038-83222038-83302021-03-0113110.4081/hr.2021.8847Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric ageLara Devilli0Chiara Garonzi1Rita Balter2Elisa Bonetti3Matteo Chinello4Ada Zaccaron5Virginia Vitale6Massimiliano De Bortoli7Giulia Caddeo8Valentina Baretta9Gloria Tridello10Simone Cesaro11Pediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaPediatric Hematology Oncology, Department of Mother and Child, Azienda Ospedaliera Universitaria Integrata, VeronaLong-term survival for acute lymphoblastic leukemia (ALL) in children improved over the last three decades up to 80-90% of affected patients. Consequently, the quality of life of survivors has become increasingly important. This study analyses the clinical features and outcome of 119 children with ALL, focusing on the quality of long-term survival in a subset of 22 patients over 18 years of age. Among this group, the 10-year event-free survival and overall survival were 83.1% (C.I. 74.0-89.2) and 88.4% (C.I. 80.9-93.1), respectively. Treatment related long-term medical complications were reported only in 2 patients (9.1%). Secondary school was completed successfully in 20 of 22 patients (89.9%). The remaining 2 patients were still attending at the time of the analysis. In conclusion, current treatment for ALL is well tolerated and does not compromise significantly the quality of life of survivors.https://www.pagepress.org/journals/index.php/hr/article/view/8847acute lymphoblastic leukemiapediatric leukemiasurvival |
| spellingShingle | Lara Devilli Chiara Garonzi Rita Balter Elisa Bonetti Matteo Chinello Ada Zaccaron Virginia Vitale Massimiliano De Bortoli Giulia Caddeo Valentina Baretta Gloria Tridello Simone Cesaro Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age Hematology Reports acute lymphoblastic leukemia pediatric leukemia survival |
| title | Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age |
| title_full | Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age |
| title_fullStr | Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age |
| title_full_unstemmed | Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age |
| title_short | Long-term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age |
| title_sort | long term and quality of survival in patients treated for acute lymphoblastic leukemia during the pediatric age |
| topic | acute lymphoblastic leukemia pediatric leukemia survival |
| url | https://www.pagepress.org/journals/index.php/hr/article/view/8847 |
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