Role of extracellular vesicles in nonalcoholic fatty liver disease
BackgroundNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that affects approximately one-quarter of the global population and is becoming increasingly prevalent worldwide. The lack of current noninvasive tools and efficient treatment is recognized as a significant barrier...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1196831/full |
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| author | Wei Jiang Youhui Xu Jou-Chen Chen Yi-Hung Lee Yushin Hu Chang-Hai Liu Enqiang Chen Hong Tang Hua Zhang Hua Zhang Hua Zhang Dongbo Wu |
| author_facet | Wei Jiang Youhui Xu Jou-Chen Chen Yi-Hung Lee Yushin Hu Chang-Hai Liu Enqiang Chen Hong Tang Hua Zhang Hua Zhang Hua Zhang Dongbo Wu |
| author_sort | Wei Jiang |
| collection | DOAJ |
| description | BackgroundNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that affects approximately one-quarter of the global population and is becoming increasingly prevalent worldwide. The lack of current noninvasive tools and efficient treatment is recognized as a significant barrier to the clinical management of these conditions. Extracellular vesicles (EVs) are nanoscale vesicles released by various cells and deliver bioactive molecules to target cells, thereby mediating various processes, including the development of NAFLD.Scope of reviewThere is still a long way to actualize the application of EVs in NAFLD diagnosis and treatment. Herein, we summarize the roles of EVs in NAFLD and highlight their prospects for clinical application as a novel noninvasive diagnostic tool as well as a promising therapy for NAFLD, owing to their unique physiochemical characteristics. We summarize the literatures on the mechanisms by which EVs act as mediators of intercellular communication by regulating metabolism, insulin resistance, inflammation, immune response, intestinal microecology, and fibrosis in NAFLD. We also discuss future challenges that must be resolved to improve the therapeutic potential of EVs.Major conclusionsThe levels and contents of EVs change dynamically at different stages of diseases and this phenomenon may be exploited for establishing sensitive stage-specific markers. EVs also have high application potential as drug delivery systems with low immunogenicity and high biocompatibility and can be easily engineered. Research on the mechanisms and clinical applications of EVs in NAFLD is in its initial phase and the applicability of EVs in NAFLD diagnosis and treatment is expected to grow with technological progress. |
| first_indexed | 2024-03-12T23:08:07Z |
| format | Article |
| id | doaj.art-eb6952b6790d4052b4168a81a13e97d7 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T23:08:07Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-eb6952b6790d4052b4168a81a13e97d72023-07-18T10:16:45ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.11968311196831Role of extracellular vesicles in nonalcoholic fatty liver diseaseWei Jiang0Youhui Xu1Jou-Chen Chen2Yi-Hung Lee3Yushin Hu4Chang-Hai Liu5Enqiang Chen6Hong Tang7Hua Zhang8Hua Zhang9Hua Zhang10Dongbo Wu11Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaWest China College of Stomatology, Sichuan University, Chengdu, ChinaWest China College of Stomatology, Sichuan University, Chengdu, ChinaWest China College of Stomatology, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu, ChinaNHC Key Laboratory of Chronobiology, Sichuan University, Chengdu, ChinaSichuan Birth Defects Clinical Research Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaCenter of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that affects approximately one-quarter of the global population and is becoming increasingly prevalent worldwide. The lack of current noninvasive tools and efficient treatment is recognized as a significant barrier to the clinical management of these conditions. Extracellular vesicles (EVs) are nanoscale vesicles released by various cells and deliver bioactive molecules to target cells, thereby mediating various processes, including the development of NAFLD.Scope of reviewThere is still a long way to actualize the application of EVs in NAFLD diagnosis and treatment. Herein, we summarize the roles of EVs in NAFLD and highlight their prospects for clinical application as a novel noninvasive diagnostic tool as well as a promising therapy for NAFLD, owing to their unique physiochemical characteristics. We summarize the literatures on the mechanisms by which EVs act as mediators of intercellular communication by regulating metabolism, insulin resistance, inflammation, immune response, intestinal microecology, and fibrosis in NAFLD. We also discuss future challenges that must be resolved to improve the therapeutic potential of EVs.Major conclusionsThe levels and contents of EVs change dynamically at different stages of diseases and this phenomenon may be exploited for establishing sensitive stage-specific markers. EVs also have high application potential as drug delivery systems with low immunogenicity and high biocompatibility and can be easily engineered. Research on the mechanisms and clinical applications of EVs in NAFLD is in its initial phase and the applicability of EVs in NAFLD diagnosis and treatment is expected to grow with technological progress.https://www.frontiersin.org/articles/10.3389/fendo.2023.1196831/fullextracellular vesicles (EV)NAFLDdiagnosistreatmentmechanisms |
| spellingShingle | Wei Jiang Youhui Xu Jou-Chen Chen Yi-Hung Lee Yushin Hu Chang-Hai Liu Enqiang Chen Hong Tang Hua Zhang Hua Zhang Hua Zhang Dongbo Wu Role of extracellular vesicles in nonalcoholic fatty liver disease Frontiers in Endocrinology extracellular vesicles (EV) NAFLD diagnosis treatment mechanisms |
| title | Role of extracellular vesicles in nonalcoholic fatty liver disease |
| title_full | Role of extracellular vesicles in nonalcoholic fatty liver disease |
| title_fullStr | Role of extracellular vesicles in nonalcoholic fatty liver disease |
| title_full_unstemmed | Role of extracellular vesicles in nonalcoholic fatty liver disease |
| title_short | Role of extracellular vesicles in nonalcoholic fatty liver disease |
| title_sort | role of extracellular vesicles in nonalcoholic fatty liver disease |
| topic | extracellular vesicles (EV) NAFLD diagnosis treatment mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1196831/full |
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