Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes

Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes

Oxidative stress and persistent inflammation are exaggerated through chronic over-nutrition and a sedentary lifestyle, resulting in insulin resistance. In type 2 diabetes (T2D), impaired insulin signaling leads to hyperglycemia and long-term complications, including metabolic liver dysfunction, resu...

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Bibliographic Details
Main Authors: Gina M. Coudriet, Meghan M. Delmastro-Greenwood, Dana M. Previte, Meghan L. Marré, Erin C. O’Connor, Elizabeth A. Novak, Garret Vincent, Kevin P. Mollen, Sojin Lee, H. Henry Dong, Jon D. Piganelli
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Antioxidants
Subjects:
SOD mimetic
metalloporphyrin
inflammation
type 2 diabetes
NAFLD
obesity
insulin resistance
Online Access:https://www.mdpi.com/2076-3921/6/4/85

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