Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

Oxidized Alginate Dopamine Conjugate: In Vitro Characterization for Nose-to-Brain Delivery Application

Background: The blood–brain barrier (BBB) bypass of dopamine (DA) is still a challenge for supplying it to the neurons of <i>Substantia Nigra</i> mainly affected by Parkinson disease. DA prodrugs have been studied to cross the BBB, overcoming the limitations of DA hydrophilicity. Therefo...

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Main Authors: Adriana Trapani, Filomena Corbo, Gennaro Agrimi, Nicoletta Ditaranto, Nicola Cioffi, Filippo Perna, Andrea Quivelli, Erika Stefàno, Paola Lunetti, Antonella Muscella, Santo Marsigliante, Antonio Cricenti, Marco Luce, Cristina Mormile, Antonino Cataldo, Stefano Bellucci
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Materials
Subjects:
dopamine
oxidized alginate
mucoadhesion
microscopy
cell viability
Online Access:https://www.mdpi.com/1996-1944/14/13/3495

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https://www.mdpi.com/1996-1944/14/13/3495

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