Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study
Abstract Background Early posttraumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI) that can induce the development of secondary brain injuries, including increased intracranial pressure, brain death, and metabolic crisis which may result in worse outcomes. It is also...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-024-03536-z |
| _version_ | 1797276510019649536 |
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| author | Nega Dagnew Baye Fikadie Dagnew Baye Assefa Agegnehu Teshome Atalo Agimas Ayenew Anmut Tilahun Mulu Endeshaw Chekol Abebe Zelalem Tilahun Muche |
| author_facet | Nega Dagnew Baye Fikadie Dagnew Baye Assefa Agegnehu Teshome Atalo Agimas Ayenew Anmut Tilahun Mulu Endeshaw Chekol Abebe Zelalem Tilahun Muche |
| author_sort | Nega Dagnew Baye |
| collection | DOAJ |
| description | Abstract Background Early posttraumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI) that can induce the development of secondary brain injuries, including increased intracranial pressure, brain death, and metabolic crisis which may result in worse outcomes. It is also a well-recognized risk factor for the development of late post-traumatic seizure and epilepsy. This study was aimed to assess the incidence and predictors of PTS among patients with moderate or severe TBI admitted to Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia. Methods and setting An institutional-based prospective follow-up study was conducted on 402 patients with TBI admitted to the neurologic unit from June 1, 2022 to January 30, 2023. A systematic sampling technique was employed. The incidence rate of occurrence of early PTS was calculated. Both bivariable and multivariable Cox proportional hazard regression was performed. The strength of the association was measured using adjusted hazard ratios with a 95% confidence interval and p-values < 0.05. Results The incidence rate of early PTS was 2.7 per 100 person-days observation. Early PTS was observed in 17.7% of TBI patients. Age 75 and above (AHR = 2.85, 95%CI: 1.58–5.39), severe TBI (AHR = 2.06, 95%CI: 1.03–3.71), epidural hematoma (AHR = 2.4, 95% CI: 1.28–4.57), brain contusion (AHR = 2.6, 95%CI: 1.07–4.09), surgical intervention (AHR = 1.7, 95%CI: 1.03–3.82), posttraumatic amnesia (AHR = 1.99, 95%CI: 1.08–3.48), history of comorbidities (AHR = 1.56, 95%CI: 1.08–3.86), and history of alcohol abuse (AHR = 3.1, 95%CI: 1.89–5.23) were potential predictors of early PTS. Conclusion The incidence of early PTS was high. Since, early PTS can worsen secondary brain damage, knowing the predictors helps to provide an effective management plan for patients likely to develop early PTS and improve their outcome. |
| first_indexed | 2024-03-07T15:29:12Z |
| format | Article |
| id | doaj.art-eb69bf47120048acaaaa3984e9da8fcf |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-07T15:29:12Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-eb69bf47120048acaaaa3984e9da8fcf2024-03-05T16:33:25ZengBMCBMC Neurology1471-23772024-01-012411710.1186/s12883-024-03536-zIncidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective studyNega Dagnew Baye0Fikadie Dagnew Baye1Assefa Agegnehu Teshome2Atalo Agimas Ayenew3Anmut Tilahun Mulu4Endeshaw Chekol Abebe5Zelalem Tilahun Muche6Department of Biomedical Sciences, College of Health Sciences, Debre Tabor UniversityDepartment of Pediatrics and Child Health, College of Health Sciences, Debre Tabor UniversityDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor UniversityDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor UniversityDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor UniversityDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor UniversityDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor UniversityAbstract Background Early posttraumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI) that can induce the development of secondary brain injuries, including increased intracranial pressure, brain death, and metabolic crisis which may result in worse outcomes. It is also a well-recognized risk factor for the development of late post-traumatic seizure and epilepsy. This study was aimed to assess the incidence and predictors of PTS among patients with moderate or severe TBI admitted to Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia. Methods and setting An institutional-based prospective follow-up study was conducted on 402 patients with TBI admitted to the neurologic unit from June 1, 2022 to January 30, 2023. A systematic sampling technique was employed. The incidence rate of occurrence of early PTS was calculated. Both bivariable and multivariable Cox proportional hazard regression was performed. The strength of the association was measured using adjusted hazard ratios with a 95% confidence interval and p-values < 0.05. Results The incidence rate of early PTS was 2.7 per 100 person-days observation. Early PTS was observed in 17.7% of TBI patients. Age 75 and above (AHR = 2.85, 95%CI: 1.58–5.39), severe TBI (AHR = 2.06, 95%CI: 1.03–3.71), epidural hematoma (AHR = 2.4, 95% CI: 1.28–4.57), brain contusion (AHR = 2.6, 95%CI: 1.07–4.09), surgical intervention (AHR = 1.7, 95%CI: 1.03–3.82), posttraumatic amnesia (AHR = 1.99, 95%CI: 1.08–3.48), history of comorbidities (AHR = 1.56, 95%CI: 1.08–3.86), and history of alcohol abuse (AHR = 3.1, 95%CI: 1.89–5.23) were potential predictors of early PTS. Conclusion The incidence of early PTS was high. Since, early PTS can worsen secondary brain damage, knowing the predictors helps to provide an effective management plan for patients likely to develop early PTS and improve their outcome.https://doi.org/10.1186/s12883-024-03536-zTraumatic brain injurySeizuresIncidenceEthiopia |
| spellingShingle | Nega Dagnew Baye Fikadie Dagnew Baye Assefa Agegnehu Teshome Atalo Agimas Ayenew Anmut Tilahun Mulu Endeshaw Chekol Abebe Zelalem Tilahun Muche Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study BMC Neurology Traumatic brain injury Seizures Incidence Ethiopia |
| title | Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study |
| title_full | Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study |
| title_fullStr | Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study |
| title_full_unstemmed | Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study |
| title_short | Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study |
| title_sort | incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in northwest ethiopia an institution based prospective study |
| topic | Traumatic brain injury Seizures Incidence Ethiopia |
| url | https://doi.org/10.1186/s12883-024-03536-z |
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