Structure–Activity Relationship of Plesiomonas shigelloides Lipid A to the Production of TNF-α, IL-1β, and IL-6 by Human and Murine Macrophages

Structure–Activity Relationship of Plesiomonas shigelloides Lipid A to the Production of TNF-α, IL-1β, and IL-6 by Human and Murine Macrophages

Plesiomonas shigelloides is a Gram-negative bacterium that is associated with diarrheal disease in humans. Lipopolysaccharide (LPS) is the main surface antigen and virulence factor of this bacterium. The lipid A (LA) moiety of LPS is the main region recognized by target cells of immune system. Here,...

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Bibliographic Details
Main Authors: Marta Kaszowska, Marta Wojcik, Jakub Siednienko, Czeslaw Lugowski, Jolanta Lukasiewicz
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
Plesiomonas
lipid A
lipopolysaccharide
proinflammatory cytokines
THP-1
BMDM
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01741/full

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