Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms

Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms

Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia are two types of hypoxia occurring in malignant tumors. They are both associated with the activation of hypoxia-inducible factor-1 (HIF-1) and nuclear factor κB (NF-κB), which induce changes in gene expressio...

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Bibliographic Details
Main Authors: Jan Korbecki, Donata Simińska, Magdalena Gąssowska-Dobrowolska, Joanna Listos, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
cycling hypoxia
hypoxia-inducible factor
low-grade inflammation
tumor
cancer
NF-κB
Online Access:https://www.mdpi.com/1422-0067/22/19/10701

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