Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension
Mannitol is commonly used in patients with increased intracranial pressure (ICP), but its effect on cerebrovascular pressure reactivity (CVPR) is uncertain. We analyzed the changes of pressure reactivity index (PRx) during the course of mannitol treatment. Methods: Twenty-one patients who received m...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-09-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S092966461300301X |
| _version_ | 1811204811517853696 |
|---|---|
| author | Sung-Chun Tang Ru-Jen Lin Jiann-Shing Shieh An-Yeu Wu Dar-Ming Lai Sheng-Jean Huang Jiann-Shing Jeng |
| author_facet | Sung-Chun Tang Ru-Jen Lin Jiann-Shing Shieh An-Yeu Wu Dar-Ming Lai Sheng-Jean Huang Jiann-Shing Jeng |
| author_sort | Sung-Chun Tang |
| collection | DOAJ |
| description | Mannitol is commonly used in patients with increased intracranial pressure (ICP), but its effect on cerebrovascular pressure reactivity (CVPR) is uncertain. We analyzed the changes of pressure reactivity index (PRx) during the course of mannitol treatment.
Methods: Twenty-one patients who received mannitol treatment for increased ICP were recruited prospectively. Continuous waveforms of arterial blood pressure (ABP) and ICP were collected simultaneously for 60 minutes (10 minutes at baseline and 50 minutes since mannitol administration) during 37 events of mannitol treatment. The correlation coefficients between the mean ABP and ICP were averaged every 10 minutes and labeled as the PRx. The linear correlation of six time points of PRx in each event was calculated to represent the trend of CVPR changes. The negative slope of correlation was defined as improvement in CVPR under mannitol treatment and vice versa.
Results: At baseline, the average of ICP was 26.0 ± 9.1 mmHg and the values of PRx were significantly correlated with ICP (p = 0.0044, r = 0.46). After mannitol administration, the average of ICP decreased significantly to 21.2 ± 11.1 mmHg (p = 0.036), and CVPR improved in 59.4 % of all events. Further analysis showed that low baseline cerebral perfusion pressure was the only hemodynamic parameter significant association with the improvement of CVPR after mannitol treatment (p = 0.039).
Conclusion: Despite lowering ICP, mannitol may have diverse effects on CVPR in patients with intracranial hypertension. Our study suggests that mannitol infusion may have a beneficial effect on CVPR, particularly in those with a low cerebral perfusion pressure at baseline. |
| first_indexed | 2024-04-12T03:20:01Z |
| format | Article |
| id | doaj.art-eb6c613b578d4a1981947144b91f7e67 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-04-12T03:20:01Z |
| publishDate | 2015-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-eb6c613b578d4a1981947144b91f7e672022-12-22T03:49:56ZengElsevierJournal of the Formosan Medical Association0929-66462015-09-01114984284810.1016/j.jfma.2013.09.002Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertensionSung-Chun Tang0Ru-Jen Lin1Jiann-Shing Shieh2An-Yeu Wu3Dar-Ming Lai4Sheng-Jean Huang5Jiann-Shing Jeng6Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, TaiwanStroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, TaiwanDepartment of Mechanical Engineering, Yuan Ze University, Tao-Yuan, TaiwanNTU-NTUH-MediaTek Innovative Medical Electronics Research Center, Taipei, TaiwanNTU-NTUH-MediaTek Innovative Medical Electronics Research Center, Taipei, TaiwanDepartment of Surgery, National Taiwan University Hospital, Taipei, TaiwanStroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, TaiwanMannitol is commonly used in patients with increased intracranial pressure (ICP), but its effect on cerebrovascular pressure reactivity (CVPR) is uncertain. We analyzed the changes of pressure reactivity index (PRx) during the course of mannitol treatment. Methods: Twenty-one patients who received mannitol treatment for increased ICP were recruited prospectively. Continuous waveforms of arterial blood pressure (ABP) and ICP were collected simultaneously for 60 minutes (10 minutes at baseline and 50 minutes since mannitol administration) during 37 events of mannitol treatment. The correlation coefficients between the mean ABP and ICP were averaged every 10 minutes and labeled as the PRx. The linear correlation of six time points of PRx in each event was calculated to represent the trend of CVPR changes. The negative slope of correlation was defined as improvement in CVPR under mannitol treatment and vice versa. Results: At baseline, the average of ICP was 26.0 ± 9.1 mmHg and the values of PRx were significantly correlated with ICP (p = 0.0044, r = 0.46). After mannitol administration, the average of ICP decreased significantly to 21.2 ± 11.1 mmHg (p = 0.036), and CVPR improved in 59.4 % of all events. Further analysis showed that low baseline cerebral perfusion pressure was the only hemodynamic parameter significant association with the improvement of CVPR after mannitol treatment (p = 0.039). Conclusion: Despite lowering ICP, mannitol may have diverse effects on CVPR in patients with intracranial hypertension. Our study suggests that mannitol infusion may have a beneficial effect on CVPR, particularly in those with a low cerebral perfusion pressure at baseline.http://www.sciencedirect.com/science/article/pii/S092966461300301Xcerebral perfusion pressurecerebrovascular pressure reactivityintracranial hypertensionmannitol |
| spellingShingle | Sung-Chun Tang Ru-Jen Lin Jiann-Shing Shieh An-Yeu Wu Dar-Ming Lai Sheng-Jean Huang Jiann-Shing Jeng Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension Journal of the Formosan Medical Association cerebral perfusion pressure cerebrovascular pressure reactivity intracranial hypertension mannitol |
| title | Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension |
| title_full | Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension |
| title_fullStr | Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension |
| title_full_unstemmed | Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension |
| title_short | Effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension |
| title_sort | effect of mannitol on cerebrovascular pressure reactivity in patients with intracranial hypertension |
| topic | cerebral perfusion pressure cerebrovascular pressure reactivity intracranial hypertension mannitol |
| url | http://www.sciencedirect.com/science/article/pii/S092966461300301X |
| work_keys_str_mv | AT sungchuntang effectofmannitoloncerebrovascularpressurereactivityinpatientswithintracranialhypertension AT rujenlin effectofmannitoloncerebrovascularpressurereactivityinpatientswithintracranialhypertension AT jiannshingshieh effectofmannitoloncerebrovascularpressurereactivityinpatientswithintracranialhypertension AT anyeuwu effectofmannitoloncerebrovascularpressurereactivityinpatientswithintracranialhypertension AT darminglai effectofmannitoloncerebrovascularpressurereactivityinpatientswithintracranialhypertension AT shengjeanhuang effectofmannitoloncerebrovascularpressurereactivityinpatientswithintracranialhypertension AT jiannshingjeng effectofmannitoloncerebrovascularpressurereactivityinpatientswithintracranialhypertension |