The Effect of Lamotrigine on Nav1.4 Voltage-Gated Sodium Channels

The Effect of Lamotrigine on Nav1.4 Voltage-Gated Sodium Channels

Lamotrigine (LTG) is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder and it has been known that LTG targets voltage-dependent sodium channels (VGSCs). In this study, we investigated the effect of LTG on the Nav1.4 Na+ current using HEK293 cells expressing mouse Nav1.4 V...

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Bibliographic Details
Main Authors:	Yoshihiko Nakatani, Haruka Masuko, Taku Amano
Format:	Article
Language:	English
Published:	Elsevier 2013-01-01
Series:	Journal of Pharmacological Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319302725

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