Association of Heart Rate Variability with Obstructive Sleep Apnea in Adults
<i>Background and Objectives</i>: Heart rate variability (HRV) analysis is a noninvasive method used to examine autonomic system function, and the clinical applications of HRV analysis have been well documented. The aim of this study is to investigate the association between HRV and the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/59/3/471 |
| _version_ | 1827748860566437888 |
|---|---|
| author | Yen-Chang Lin Jui-Kun Chiang Chih-Ming Lu Yee-Hsin Kao |
| author_facet | Yen-Chang Lin Jui-Kun Chiang Chih-Ming Lu Yee-Hsin Kao |
| author_sort | Yen-Chang Lin |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Heart rate variability (HRV) analysis is a noninvasive method used to examine autonomic system function, and the clinical applications of HRV analysis have been well documented. The aim of this study is to investigate the association between HRV and the apnea–hypopnea index (AHI) in patients referred for polysomnography (PSG) for obstructive sleep apnea (OSA) diagnosis. <i>Materials and Methods</i>: Patients underwent whole-night PSG. Data on nocturnal HRV and AHI were analyzed. We determined the correlation of time- and frequency-domain parameters of HRV with the AHI. <i>Results</i>: A total of 62 participants (50 men and 12 women) were enrolled. The mean age, body mass index (BMI), neck circumference, and AHI score of the patients were 44.4 ± 11.5 years, 28.7 ± 5.2, 40.2 ± 4.8 cm, and 32.1 ± 27.0, respectively. The log root mean square of successive differences between normal heartbeats (RMSSD) were negatively correlated with BMI (<i>p</i> = 0.034) and neck circumference (<i>p</i> = 0.003). The log absolute power of the low-frequency band over high-frequency band (LF/HF) ratio was positively correlated with the AHI (<i>p</i> = 0.006). A higher log LF/HF power ratio (<i>β</i> = 5.01, <i>p</i> = 0.029) and BMI (<i>β</i> = 2.20, <i>p</i> < 0.001) were associated with a higher AHI value in multiple linear regression analysis. <i>Conclusions</i>: A higher log LF/HF power ratio and BMI were positively and significantly associated with the AHI during whole-night PSG in adult patients. |
| first_indexed | 2024-03-11T06:12:52Z |
| format | Article |
| id | doaj.art-eb6c81c397534158a5a222c87158e7b0 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T06:12:52Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-eb6c81c397534158a5a222c87158e7b02023-11-17T12:31:06ZengMDPI AGMedicina1010-660X1648-91442023-02-0159347110.3390/medicina59030471Association of Heart Rate Variability with Obstructive Sleep Apnea in AdultsYen-Chang Lin0Jui-Kun Chiang1Chih-Ming Lu2Yee-Hsin Kao3Nature Dental Clinic, Puli Township, Nantou 404, TaiwanDepartment of Family Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Minsheng Road, Dalin, Chiayi 622, TaiwanDepartment of Urology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Minsheng Road, Dalin, Chiayi 622, TaiwanDepartment of Family Medicine, Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), 670 Chung-Te Road, Tainan 701, Taiwan<i>Background and Objectives</i>: Heart rate variability (HRV) analysis is a noninvasive method used to examine autonomic system function, and the clinical applications of HRV analysis have been well documented. The aim of this study is to investigate the association between HRV and the apnea–hypopnea index (AHI) in patients referred for polysomnography (PSG) for obstructive sleep apnea (OSA) diagnosis. <i>Materials and Methods</i>: Patients underwent whole-night PSG. Data on nocturnal HRV and AHI were analyzed. We determined the correlation of time- and frequency-domain parameters of HRV with the AHI. <i>Results</i>: A total of 62 participants (50 men and 12 women) were enrolled. The mean age, body mass index (BMI), neck circumference, and AHI score of the patients were 44.4 ± 11.5 years, 28.7 ± 5.2, 40.2 ± 4.8 cm, and 32.1 ± 27.0, respectively. The log root mean square of successive differences between normal heartbeats (RMSSD) were negatively correlated with BMI (<i>p</i> = 0.034) and neck circumference (<i>p</i> = 0.003). The log absolute power of the low-frequency band over high-frequency band (LF/HF) ratio was positively correlated with the AHI (<i>p</i> = 0.006). A higher log LF/HF power ratio (<i>β</i> = 5.01, <i>p</i> = 0.029) and BMI (<i>β</i> = 2.20, <i>p</i> < 0.001) were associated with a higher AHI value in multiple linear regression analysis. <i>Conclusions</i>: A higher log LF/HF power ratio and BMI were positively and significantly associated with the AHI during whole-night PSG in adult patients.https://www.mdpi.com/1648-9144/59/3/471heart rate variability (HRV)the apnea-hypopnea index (AHI)obstructive sleep apnea (OSA)polysomnography (PSG) |
| spellingShingle | Yen-Chang Lin Jui-Kun Chiang Chih-Ming Lu Yee-Hsin Kao Association of Heart Rate Variability with Obstructive Sleep Apnea in Adults Medicina heart rate variability (HRV) the apnea-hypopnea index (AHI) obstructive sleep apnea (OSA) polysomnography (PSG) |
| title | Association of Heart Rate Variability with Obstructive Sleep Apnea in Adults |
| title_full | Association of Heart Rate Variability with Obstructive Sleep Apnea in Adults |
| title_fullStr | Association of Heart Rate Variability with Obstructive Sleep Apnea in Adults |
| title_full_unstemmed | Association of Heart Rate Variability with Obstructive Sleep Apnea in Adults |
| title_short | Association of Heart Rate Variability with Obstructive Sleep Apnea in Adults |
| title_sort | association of heart rate variability with obstructive sleep apnea in adults |
| topic | heart rate variability (HRV) the apnea-hypopnea index (AHI) obstructive sleep apnea (OSA) polysomnography (PSG) |
| url | https://www.mdpi.com/1648-9144/59/3/471 |
| work_keys_str_mv | AT yenchanglin associationofheartratevariabilitywithobstructivesleepapneainadults AT juikunchiang associationofheartratevariabilitywithobstructivesleepapneainadults AT chihminglu associationofheartratevariabilitywithobstructivesleepapneainadults AT yeehsinkao associationofheartratevariabilitywithobstructivesleepapneainadults |