Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case Study
<p>Abstract</p> <p>Background</p> <p>Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing. Aspirin is known to affe...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-06-01
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| Series: | BMC Pulmonary Medicine |
| Online Access: | http://www.biomedcentral.com/1471-2466/10/34 |
| _version_ | 1818488574783258624 |
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| author | Choi Inseon S Kim Mi-Kyeong Uh Soo-Taek Park Sung-Woo Park Jong-Sook Cheong Hyun Sub Park Byung Lae Pasaje Charisse Lee Jin Sol Bae Joon Seol Park Tae Joon Kim Jason Kim Jeong Hyun Cho Sang Heon Choi Byoung Whui Park Choon-Sik Shin Hyoung Doo |
| author_facet | Choi Inseon S Kim Mi-Kyeong Uh Soo-Taek Park Sung-Woo Park Jong-Sook Cheong Hyun Sub Park Byung Lae Pasaje Charisse Lee Jin Sol Bae Joon Seol Park Tae Joon Kim Jason Kim Jeong Hyun Cho Sang Heon Choi Byoung Whui Park Choon-Sik Shin Hyoung Doo |
| author_sort | Choi Inseon S |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing. Aspirin is known to affect various parts inside human body, ranging from lung to spermatogenesis. <it>FSIP1</it>, also known as <it>HDS10</it>, is a recently discovered gene that encodes fibrous sheath interacting protein 1, and is regulated by amyloid beta precursor protein (APP). Recently, it has been reported that a peptide derived from APP is cleaved by α disintegrin and metalloproteinase 33 (<it>ADAM33</it>), which is an asthma susceptibility gene. It has also been known that the <it>FSIP1 </it>gene is expressed in airway epithelium.</p> <p>Objectives</p> <p>Aim of this study is to find out whether <it>FSIP1 </it>polymorphisms affect the onset of AIA in Korean population, since it is known that AIA is genetically affected by various genes.</p> <p>Methods</p> <p>We conducted association study between 66 single nucleotide polymorphisms (SNPs) of the <it>FSIP1 </it>gene and AIA in total of 592 Korean subjects including 163 AIA and 429 aspirin-tolerant asthma (ATA) patients. Associations between polymorphisms of <it>FSIP1 </it>and AIA were analyzed with sex, smoking status, atopy, and body mass index (BMI) as covariates.</p> <p>Results</p> <p>Initially, 18 SNPs and 4 haplotypes showed associations with AIA. However, after correcting the data for multiple testing, only one SNP showed an association with AIA (corrected <it>P</it>-value = 0.03, OR = 1.63, 95% CI = 1.23-2.16), showing increased susceptibility to AIA compared with that of ATA cases. Our findings suggest that <it>FSIP1 </it>gene might be a susceptibility gene for aspirin intolerance in asthmatics.</p> <p>Conclusion</p> <p>Although our findings did not suggest that SNPs of <it>FSIP1 </it>had an effect on the reversibility of lung function abnormalities in AIA patients, they did show significant evidence of association between the variants in <it>FSIP1 </it>and AIA occurrence among asthmatics in a Korean population.</p> |
| first_indexed | 2024-12-10T16:52:58Z |
| format | Article |
| id | doaj.art-eb6ca148200f4cb780710ff8a70b45bd |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-10T16:52:58Z |
| publishDate | 2010-06-01 |
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| series | BMC Pulmonary Medicine |
| spelling | doaj.art-eb6ca148200f4cb780710ff8a70b45bd2022-12-22T01:40:51ZengBMCBMC Pulmonary Medicine1471-24662010-06-011013410.1186/1471-2466-10-34Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case StudyChoi Inseon SKim Mi-KyeongUh Soo-TaekPark Sung-WooPark Jong-SookCheong Hyun SubPark Byung LaePasaje CharisseLee Jin SolBae Joon SeolPark Tae JoonKim JasonKim Jeong HyunCho Sang HeonChoi Byoung WhuiPark Choon-SikShin Hyoung Doo<p>Abstract</p> <p>Background</p> <p>Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing. Aspirin is known to affect various parts inside human body, ranging from lung to spermatogenesis. <it>FSIP1</it>, also known as <it>HDS10</it>, is a recently discovered gene that encodes fibrous sheath interacting protein 1, and is regulated by amyloid beta precursor protein (APP). Recently, it has been reported that a peptide derived from APP is cleaved by α disintegrin and metalloproteinase 33 (<it>ADAM33</it>), which is an asthma susceptibility gene. It has also been known that the <it>FSIP1 </it>gene is expressed in airway epithelium.</p> <p>Objectives</p> <p>Aim of this study is to find out whether <it>FSIP1 </it>polymorphisms affect the onset of AIA in Korean population, since it is known that AIA is genetically affected by various genes.</p> <p>Methods</p> <p>We conducted association study between 66 single nucleotide polymorphisms (SNPs) of the <it>FSIP1 </it>gene and AIA in total of 592 Korean subjects including 163 AIA and 429 aspirin-tolerant asthma (ATA) patients. Associations between polymorphisms of <it>FSIP1 </it>and AIA were analyzed with sex, smoking status, atopy, and body mass index (BMI) as covariates.</p> <p>Results</p> <p>Initially, 18 SNPs and 4 haplotypes showed associations with AIA. However, after correcting the data for multiple testing, only one SNP showed an association with AIA (corrected <it>P</it>-value = 0.03, OR = 1.63, 95% CI = 1.23-2.16), showing increased susceptibility to AIA compared with that of ATA cases. Our findings suggest that <it>FSIP1 </it>gene might be a susceptibility gene for aspirin intolerance in asthmatics.</p> <p>Conclusion</p> <p>Although our findings did not suggest that SNPs of <it>FSIP1 </it>had an effect on the reversibility of lung function abnormalities in AIA patients, they did show significant evidence of association between the variants in <it>FSIP1 </it>and AIA occurrence among asthmatics in a Korean population.</p>http://www.biomedcentral.com/1471-2466/10/34 |
| spellingShingle | Choi Inseon S Kim Mi-Kyeong Uh Soo-Taek Park Sung-Woo Park Jong-Sook Cheong Hyun Sub Park Byung Lae Pasaje Charisse Lee Jin Sol Bae Joon Seol Park Tae Joon Kim Jason Kim Jeong Hyun Cho Sang Heon Choi Byoung Whui Park Choon-Sik Shin Hyoung Doo Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case Study BMC Pulmonary Medicine |
| title | Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case Study |
| title_full | Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case Study |
| title_fullStr | Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case Study |
| title_full_unstemmed | Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case Study |
| title_short | Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of <it>FSIP1</it>: a Case-Case Study |
| title_sort | positive association between aspirin intolerant asthma and genetic polymorphisms of it fsip1 it a case case study |
| url | http://www.biomedcentral.com/1471-2466/10/34 |
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