The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease
The pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor region, involved in the control of gait and locomotion. The PPN contains glutamatergic, cholinergic, and GABAergic neurons that all make local connections, but also have long-range ascending and descending connection...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2023.1095441/full |
| _version_ | 1797893811992526848 |
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| author | Caixia Lin Caixia Lin Margreet C. Ridder Pankaj Sah Pankaj Sah |
| author_facet | Caixia Lin Caixia Lin Margreet C. Ridder Pankaj Sah Pankaj Sah |
| author_sort | Caixia Lin |
| collection | DOAJ |
| description | The pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor region, involved in the control of gait and locomotion. The PPN contains glutamatergic, cholinergic, and GABAergic neurons that all make local connections, but also have long-range ascending and descending connections. While initially thought of as a region only involved in gait and locomotion, recent evidence is showing that this structure also participates in decision-making to initiate movement. Clinically, the PPN has been used as a target for deep brain stimulation to manage freezing of gait in late Parkinson’s disease. In this review, we will discuss current thinking on the role of the PPN in locomotor control. We will focus on the cytoarchitecture and functional connectivity of the PPN in relationship to motor control. |
| first_indexed | 2024-04-10T06:58:47Z |
| format | Article |
| id | doaj.art-eb6f2da47eb54049a70b67093dc97a56 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-10T06:58:47Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-eb6f2da47eb54049a70b67093dc97a562023-02-28T04:48:10ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102023-02-011710.3389/fncir.2023.10954411095441The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s diseaseCaixia Lin0Caixia Lin1Margreet C. Ridder2Pankaj Sah3Pankaj Sah4Queensland Brain Institute, University of Queensland, St Lucia, QLD, AustraliaJoint Centre for Neuroscience and Neural Engineering, and Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong Province, ChinaQueensland Brain Institute, University of Queensland, St Lucia, QLD, AustraliaQueensland Brain Institute, University of Queensland, St Lucia, QLD, AustraliaJoint Centre for Neuroscience and Neural Engineering, and Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong Province, ChinaThe pedunculopontine nucleus (PPN) is the major part of the mesencephalic locomotor region, involved in the control of gait and locomotion. The PPN contains glutamatergic, cholinergic, and GABAergic neurons that all make local connections, but also have long-range ascending and descending connections. While initially thought of as a region only involved in gait and locomotion, recent evidence is showing that this structure also participates in decision-making to initiate movement. Clinically, the PPN has been used as a target for deep brain stimulation to manage freezing of gait in late Parkinson’s disease. In this review, we will discuss current thinking on the role of the PPN in locomotor control. We will focus on the cytoarchitecture and functional connectivity of the PPN in relationship to motor control.https://www.frontiersin.org/articles/10.3389/fncir.2023.1095441/fullmotor controlbasal gangliacholinergicmovementgait |
| spellingShingle | Caixia Lin Caixia Lin Margreet C. Ridder Pankaj Sah Pankaj Sah The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease Frontiers in Neural Circuits motor control basal ganglia cholinergic movement gait |
| title | The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease |
| title_full | The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease |
| title_fullStr | The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease |
| title_full_unstemmed | The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease |
| title_short | The PPN and motor control: Preclinical studies to deep brain stimulation for Parkinson’s disease |
| title_sort | ppn and motor control preclinical studies to deep brain stimulation for parkinson s disease |
| topic | motor control basal ganglia cholinergic movement gait |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2023.1095441/full |
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