Impact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with Obesity
Background: Childhood obesity has been suggested as a risk factor for bronchial asthma. The aim of this study was to clarify the relationship between clinical factors related to obesity, including adipocytokines and eosinophilic inflammation, as candidate pathogenesis mechanisms of bronchial asthma...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Tokyo Women's Medical University
2020-03-01
|
| Series: | Tokyo Women's Medical University Journal |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/twmuj/4/0/4_2019103/_pdf/-char/en |
| _version_ | 1819076776583757824 |
|---|---|
| author | Norihiko Azuma Tomoko Otani Midori Kotani Yuki Yasuda Hisafumi Matsuoka Satoru Shimizu Shigetaka Sugihara |
| author_facet | Norihiko Azuma Tomoko Otani Midori Kotani Yuki Yasuda Hisafumi Matsuoka Satoru Shimizu Shigetaka Sugihara |
| author_sort | Norihiko Azuma |
| collection | DOAJ |
| description | Background: Childhood obesity has been suggested as a risk factor for bronchial asthma. The aim of this study was to clarify the relationship between clinical factors related to obesity, including adipocytokines and eosinophilic inflammation, as candidate pathogenesis mechanisms of bronchial asthma in Japanese children and adolescents.Methods: Forty-one children and adolescents visiting our outpatient clinic were enrolled. The relationship between participants' clinical and demographic characteristics and fraction of exhaled nitric oxide (FENO) or blood eosinophil (B-Eos) count values were analyzed.Results: No significant correlation was observed between either FENO or B-Eos count values and the body mass index z-score. FENO was high (≥35 ppb) in 8 cases and normal (<35 ppb) in 33 cases. Adiponectin was significantly lower in the high FENO group than in the normal FENO group (6.5 vs. 8.1 μg/mL, p<0.02). A negative correlation between B-Eos count values and adiponectin levels (r=∁E.34, p<0.05) and a positive correlation between B-Eos count values and plasminogen activator inhibitor-1 levels were noted (r=0.42, p<0.01). The univariable odds ratio of adiponectin for high FENO was 0.62 (0.41-0.95) and the association was borderline after adjusting for B-Eos.Conclusions: Eosinophilic inflammation was associated with a decrease in serum adiponectin levels which may be induced by visceral fat accumulation. |
| first_indexed | 2024-12-21T18:46:41Z |
| format | Article |
| id | doaj.art-eb70a2d3cd4d4897936a447b1ee5679c |
| institution | Directory Open Access Journal |
| issn | 2432-6186 |
| language | English |
| last_indexed | 2024-12-21T18:46:41Z |
| publishDate | 2020-03-01 |
| publisher | Society of Tokyo Women's Medical University |
| record_format | Article |
| series | Tokyo Women's Medical University Journal |
| spelling | doaj.art-eb70a2d3cd4d4897936a447b1ee5679c2022-12-21T18:53:53ZengSociety of Tokyo Women's Medical UniversityTokyo Women's Medical University Journal2432-61862020-03-0140334310.24488/twmuj.2019103twmujImpact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with ObesityNorihiko Azuma0Tomoko Otani1Midori Kotani2Yuki Yasuda3Hisafumi Matsuoka4Satoru Shimizu5Shigetaka Sugihara6Department of Pediatrics, Tokyo Women's Medical University Medical Center EastDepartment of Pediatrics, Tokyo Women's Medical University Medical Center EastDepartment of Pediatrics, Tokyo Women's Medical University Medical Center EastDepartment of Pediatrics, Tokyo Women's Medical University Medical Center EastDepartment of Pediatrics, Tokyo Women's Medical University Medical Center EastDepartment of Medical Education, Tokyo Women's Medical UniversityDepartment of Pediatrics, Tokyo Women's Medical University Medical Center EastBackground: Childhood obesity has been suggested as a risk factor for bronchial asthma. The aim of this study was to clarify the relationship between clinical factors related to obesity, including adipocytokines and eosinophilic inflammation, as candidate pathogenesis mechanisms of bronchial asthma in Japanese children and adolescents.Methods: Forty-one children and adolescents visiting our outpatient clinic were enrolled. The relationship between participants' clinical and demographic characteristics and fraction of exhaled nitric oxide (FENO) or blood eosinophil (B-Eos) count values were analyzed.Results: No significant correlation was observed between either FENO or B-Eos count values and the body mass index z-score. FENO was high (≥35 ppb) in 8 cases and normal (<35 ppb) in 33 cases. Adiponectin was significantly lower in the high FENO group than in the normal FENO group (6.5 vs. 8.1 μg/mL, p<0.02). A negative correlation between B-Eos count values and adiponectin levels (r=∁E.34, p<0.05) and a positive correlation between B-Eos count values and plasminogen activator inhibitor-1 levels were noted (r=0.42, p<0.01). The univariable odds ratio of adiponectin for high FENO was 0.62 (0.41-0.95) and the association was borderline after adjusting for B-Eos.Conclusions: Eosinophilic inflammation was associated with a decrease in serum adiponectin levels which may be induced by visceral fat accumulation.https://www.jstage.jst.go.jp/article/twmuj/4/0/4_2019103/_pdf/-char/enadiponectinchildhood obesityeosinophilic inflammationbronchial asthmafraction of exhaled nitric oxide |
| spellingShingle | Norihiko Azuma Tomoko Otani Midori Kotani Yuki Yasuda Hisafumi Matsuoka Satoru Shimizu Shigetaka Sugihara Impact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with Obesity Tokyo Women's Medical University Journal adiponectin childhood obesity eosinophilic inflammation bronchial asthma fraction of exhaled nitric oxide |
| title | Impact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with Obesity |
| title_full | Impact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with Obesity |
| title_fullStr | Impact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with Obesity |
| title_full_unstemmed | Impact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with Obesity |
| title_short | Impact of Serum Adiponectin, Plasminogen Activator Inhibitor-1, and Oxidative Stress Levels on Eosinophilic Inflammation of the Airway and the Whole Body in Children with Obesity |
| title_sort | impact of serum adiponectin plasminogen activator inhibitor 1 and oxidative stress levels on eosinophilic inflammation of the airway and the whole body in children with obesity |
| topic | adiponectin childhood obesity eosinophilic inflammation bronchial asthma fraction of exhaled nitric oxide |
| url | https://www.jstage.jst.go.jp/article/twmuj/4/0/4_2019103/_pdf/-char/en |
| work_keys_str_mv | AT norihikoazuma impactofserumadiponectinplasminogenactivatorinhibitor1andoxidativestresslevelsoneosinophilicinflammationoftheairwayandthewholebodyinchildrenwithobesity AT tomokootani impactofserumadiponectinplasminogenactivatorinhibitor1andoxidativestresslevelsoneosinophilicinflammationoftheairwayandthewholebodyinchildrenwithobesity AT midorikotani impactofserumadiponectinplasminogenactivatorinhibitor1andoxidativestresslevelsoneosinophilicinflammationoftheairwayandthewholebodyinchildrenwithobesity AT yukiyasuda impactofserumadiponectinplasminogenactivatorinhibitor1andoxidativestresslevelsoneosinophilicinflammationoftheairwayandthewholebodyinchildrenwithobesity AT hisafumimatsuoka impactofserumadiponectinplasminogenactivatorinhibitor1andoxidativestresslevelsoneosinophilicinflammationoftheairwayandthewholebodyinchildrenwithobesity AT satorushimizu impactofserumadiponectinplasminogenactivatorinhibitor1andoxidativestresslevelsoneosinophilicinflammationoftheairwayandthewholebodyinchildrenwithobesity AT shigetakasugihara impactofserumadiponectinplasminogenactivatorinhibitor1andoxidativestresslevelsoneosinophilicinflammationoftheairwayandthewholebodyinchildrenwithobesity |