Pathophysiology of bladder dysfunction in Parkinson's disease
Bladder dysfunction (urinary urgency/frequency) is a common non-motor disorder in Parkinson's disease (PD). In contrast to motor disorders, bladder dysfunction is sometimes non-responsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) inv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2012-06-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996111003342 |
| _version_ | 1818869943185178624 |
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| author | Ryuji Sakakibara Fuyuki Tateno Masahiko Kishi Yohei Tsuyuzaki Tomoyuki Uchiyama Tatsuya Yamamoto |
| author_facet | Ryuji Sakakibara Fuyuki Tateno Masahiko Kishi Yohei Tsuyuzaki Tomoyuki Uchiyama Tatsuya Yamamoto |
| author_sort | Ryuji Sakakibara |
| collection | DOAJ |
| description | Bladder dysfunction (urinary urgency/frequency) is a common non-motor disorder in Parkinson's disease (PD). In contrast to motor disorders, bladder dysfunction is sometimes non-responsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine basal ganglia-frontal circuit, which normally suppresses the micturition reflex. The pathophysiology of the bladder dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. These treatments might be beneficial in maximizing the patients' quality of life. |
| first_indexed | 2024-12-19T11:59:09Z |
| format | Article |
| id | doaj.art-eb7174aeaae34ee28d108f6cc4d6f444 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-19T11:59:09Z |
| publishDate | 2012-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-eb7174aeaae34ee28d108f6cc4d6f4442022-12-21T20:22:33ZengElsevierNeurobiology of Disease1095-953X2012-06-01463565571Pathophysiology of bladder dysfunction in Parkinson's diseaseRyuji Sakakibara0Fuyuki Tateno1Masahiko Kishi2Yohei Tsuyuzaki3Tomoyuki Uchiyama4Tatsuya Yamamoto5Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan; Corresponding author at: Neurology Division, Department of Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura, 285-8741 Japan. Fax: +81 43 462 8820.Neurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, JapanNeurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, JapanNeurology, Internal Medicine, Sakura Medical Center, Toho University, Sakura, JapanNeurology, Chiba University, Chiba, JapanNeurology, Chiba University, Chiba, JapanBladder dysfunction (urinary urgency/frequency) is a common non-motor disorder in Parkinson's disease (PD). In contrast to motor disorders, bladder dysfunction is sometimes non-responsive to levodopa treatment. The brain pathology causing the bladder dysfunction (appearance of overactivity) involves an altered dopamine basal ganglia-frontal circuit, which normally suppresses the micturition reflex. The pathophysiology of the bladder dysfunction in PD differs from that in multiple system atrophy; therefore, it might aid in differential diagnosis. Anticholinergic agents are used to treat bladder dysfunction in PD, although these drugs should be used with caution particularly in elderly patients who have cognitive decline. These treatments might be beneficial in maximizing the patients' quality of life.http://www.sciencedirect.com/science/article/pii/S0969996111003342Parkinson's diseaseBladder dysfunctionDopamine D1 receptors |
| spellingShingle | Ryuji Sakakibara Fuyuki Tateno Masahiko Kishi Yohei Tsuyuzaki Tomoyuki Uchiyama Tatsuya Yamamoto Pathophysiology of bladder dysfunction in Parkinson's disease Neurobiology of Disease Parkinson's disease Bladder dysfunction Dopamine D1 receptors |
| title | Pathophysiology of bladder dysfunction in Parkinson's disease |
| title_full | Pathophysiology of bladder dysfunction in Parkinson's disease |
| title_fullStr | Pathophysiology of bladder dysfunction in Parkinson's disease |
| title_full_unstemmed | Pathophysiology of bladder dysfunction in Parkinson's disease |
| title_short | Pathophysiology of bladder dysfunction in Parkinson's disease |
| title_sort | pathophysiology of bladder dysfunction in parkinson s disease |
| topic | Parkinson's disease Bladder dysfunction Dopamine D1 receptors |
| url | http://www.sciencedirect.com/science/article/pii/S0969996111003342 |
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