The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

The histone deacetylase HDAC2, which negatively regulates synaptic gene expression and neuronal plasticity, is upregulated in Alzheimer’s disease (AD) patients and mouse models. Therapeutics targeting HDAC2 hold promise for ameliorating AD-related cognitive impairment; however, attempts to generate...

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Bibliographic Details
Main Authors: Hidekuni Yamakawa, Jemmie Cheng, Jay Penney, Fan Gao, Richard Rueda, Jun Wang, Satoko Yamakawa, Oleg Kritskiy, Elizabeta Gjoneska, Li-Huei Tsai
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
synaptic plasticity
histone acetylation
epigenetic
memory
Alzheimer’s disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310239

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