Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits
Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05428-6 |
| _version_ | 1818681799832764416 |
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| author | Thorunn Rafnar Bjarni Gunnarsson Olafur A. Stefansson Patrick Sulem Andres Ingason Michael L. Frigge Lilja Stefansdottir Jon K. Sigurdsson Vinicius Tragante Valgerdur Steinthorsdottir Unnur Styrkarsdottir Simon N. Stacey Julius Gudmundsson Gudny A. Arnadottir Asmundur Oddsson Florian Zink Gisli Halldorsson Gardar Sveinbjornsson Ragnar P. Kristjansson Olafur B. Davidsson Anna Salvarsdottir Asgeir Thoroddsen Elisabet A. Helgadottir Katrin Kristjansdottir Orri Ingthorsson Valur Gudmundsson Reynir T. Geirsson Ragnheidur Arnadottir Daniel F. Gudbjartsson Gisli Masson Folkert W. Asselbergs Jon G. Jonasson Karl Olafsson Unnur Thorsteinsdottir Bjarni V. Halldorsson Gudmar Thorleifsson Kari Stefansson |
| author_facet | Thorunn Rafnar Bjarni Gunnarsson Olafur A. Stefansson Patrick Sulem Andres Ingason Michael L. Frigge Lilja Stefansdottir Jon K. Sigurdsson Vinicius Tragante Valgerdur Steinthorsdottir Unnur Styrkarsdottir Simon N. Stacey Julius Gudmundsson Gudny A. Arnadottir Asmundur Oddsson Florian Zink Gisli Halldorsson Gardar Sveinbjornsson Ragnar P. Kristjansson Olafur B. Davidsson Anna Salvarsdottir Asgeir Thoroddsen Elisabet A. Helgadottir Katrin Kristjansdottir Orri Ingthorsson Valur Gudmundsson Reynir T. Geirsson Ragnheidur Arnadottir Daniel F. Gudbjartsson Gisli Masson Folkert W. Asselbergs Jon G. Jonasson Karl Olafsson Unnur Thorsteinsdottir Bjarni V. Halldorsson Gudmar Thorleifsson Kari Stefansson |
| author_sort | Thorunn Rafnar |
| collection | DOAJ |
| description | Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth. |
| first_indexed | 2024-12-17T10:08:42Z |
| format | Article |
| id | doaj.art-eb7406c94cd54be79b2b3ac5e46f33e9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:08:42Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-eb7406c94cd54be79b2b3ac5e46f33e92022-12-21T21:53:06ZengNature PortfolioNature Communications2041-17232018-09-01911910.1038/s41467-018-05428-6Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traitsThorunn Rafnar0Bjarni Gunnarsson1Olafur A. Stefansson2Patrick Sulem3Andres Ingason4Michael L. Frigge5Lilja Stefansdottir6Jon K. Sigurdsson7Vinicius Tragante8Valgerdur Steinthorsdottir9Unnur Styrkarsdottir10Simon N. Stacey11Julius Gudmundsson12Gudny A. Arnadottir13Asmundur Oddsson14Florian Zink15Gisli Halldorsson16Gardar Sveinbjornsson17Ragnar P. Kristjansson18Olafur B. Davidsson19Anna Salvarsdottir20Asgeir Thoroddsen21Elisabet A. Helgadottir22Katrin Kristjansdottir23Orri Ingthorsson24Valur Gudmundsson25Reynir T. Geirsson26Ragnheidur Arnadottir27Daniel F. Gudbjartsson28Gisli Masson29Folkert W. Asselbergs30Jon G. Jonasson31Karl Olafsson32Unnur Thorsteinsdottir33Bjarni V. Halldorsson34Gudmar Thorleifsson35Kari Stefansson36deCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgenDepartment of Obstetrics and Gynecology, Landspitali University HospitalDepartment of Obstetrics and Gynecology, Landspitali University HospitalDepartment of Obstetrics and Gynecology, Landspitali University HospitalDepartment of Obstetrics and Gynecology, Landspitali University HospitalDepartment of Obstetrics and Gynecology, Akureyri HospitalDepartment of Obstetrics and Gynecology, Akureyri HospitalDepartment of Obstetrics and Gynecology, Landspitali University HospitalDepartment of Obstetrics and Gynecology, Landspitali University HospitaldeCODE Genetics/AmgendeCODE Genetics/AmgenDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of UtrechtFaculty of Medicine, School of Health Sciences, University of IcelandDepartment of Obstetrics and Gynecology, Landspitali University HospitaldeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgendeCODE Genetics/AmgenUterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth.https://doi.org/10.1038/s41467-018-05428-6 |
| spellingShingle | Thorunn Rafnar Bjarni Gunnarsson Olafur A. Stefansson Patrick Sulem Andres Ingason Michael L. Frigge Lilja Stefansdottir Jon K. Sigurdsson Vinicius Tragante Valgerdur Steinthorsdottir Unnur Styrkarsdottir Simon N. Stacey Julius Gudmundsson Gudny A. Arnadottir Asmundur Oddsson Florian Zink Gisli Halldorsson Gardar Sveinbjornsson Ragnar P. Kristjansson Olafur B. Davidsson Anna Salvarsdottir Asgeir Thoroddsen Elisabet A. Helgadottir Katrin Kristjansdottir Orri Ingthorsson Valur Gudmundsson Reynir T. Geirsson Ragnheidur Arnadottir Daniel F. Gudbjartsson Gisli Masson Folkert W. Asselbergs Jon G. Jonasson Karl Olafsson Unnur Thorsteinsdottir Bjarni V. Halldorsson Gudmar Thorleifsson Kari Stefansson Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits Nature Communications |
| title | Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_full | Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_fullStr | Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_full_unstemmed | Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_short | Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits |
| title_sort | variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone related traits |
| url | https://doi.org/10.1038/s41467-018-05428-6 |
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