Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates
Few studies have reported the use of double-filtration plasmapheresis (DFPP) in antibody-incompatible kidney transplantation. To assess the efficiency and tolerability of DFPP, we prospectively studied four chronic hemodialysis patients from two centers undergoing antibody-incompatible kidney transp...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=2;spage=297;epage=301;aulast=Hebibi |
| _version_ | 1811321503577276416 |
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| author | Hadia Hebibi Hugo Weclawiak Lionel Rostaing Séverine Beaudreuil Asma Allal Hélène François Antoine Durrbach Nassim Kamar |
| author_facet | Hadia Hebibi Hugo Weclawiak Lionel Rostaing Séverine Beaudreuil Asma Allal Hélène François Antoine Durrbach Nassim Kamar |
| author_sort | Hadia Hebibi |
| collection | DOAJ |
| description | Few studies have reported the use of double-filtration plasmapheresis (DFPP) in antibody-incompatible kidney transplantation. To assess the efficiency and tolerability of DFPP, we prospectively studied four chronic hemodialysis patients from two centers undergoing antibody-incompatible kidney transplantation. DFPP was used for ABO-incompatible transplantation (n = 1), for high human leukocyte antigen (HLA) immunization levels (n = 2) or for the presence of a donor-specific antibody (DSA) against a potential living donor (n = 1). In all the patients, the DFPP program was discontinued because of the adverse effects. Low blood pressure occurred during the first hour of the session in all the patients. A significant loss of plasma proteins, clotting factors and immunoglobulins also occurred during this treatment. In addition, fistula thrombosis was diagnosed in two patients. Three patients experienced gastrointestinal symptoms. The DFPP reduced the titers of the anti-B antibodies and reduced the levels of DSA in one patient, but had no effect on anti-HLA antibodies in the remaining two patients. Our study highlights the non-tolerability and poor efficacy of DFPP prior to antibody-incompatible kidney transplantation that limit its extensive use in the desensitization protocols. |
| first_indexed | 2024-04-13T13:17:55Z |
| format | Article |
| id | doaj.art-eb7433ee92da488aa4112f6e3cb88bff |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-04-13T13:17:55Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-eb7433ee92da488aa4112f6e3cb88bff2022-12-22T02:45:24ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422015-01-0126229730110.4103/1319-2442.152435Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidatesHadia HebibiHugo WeclawiakLionel RostaingSéverine BeaudreuilAsma AllalHélène FrançoisAntoine DurrbachNassim KamarFew studies have reported the use of double-filtration plasmapheresis (DFPP) in antibody-incompatible kidney transplantation. To assess the efficiency and tolerability of DFPP, we prospectively studied four chronic hemodialysis patients from two centers undergoing antibody-incompatible kidney transplantation. DFPP was used for ABO-incompatible transplantation (n = 1), for high human leukocyte antigen (HLA) immunization levels (n = 2) or for the presence of a donor-specific antibody (DSA) against a potential living donor (n = 1). In all the patients, the DFPP program was discontinued because of the adverse effects. Low blood pressure occurred during the first hour of the session in all the patients. A significant loss of plasma proteins, clotting factors and immunoglobulins also occurred during this treatment. In addition, fistula thrombosis was diagnosed in two patients. Three patients experienced gastrointestinal symptoms. The DFPP reduced the titers of the anti-B antibodies and reduced the levels of DSA in one patient, but had no effect on anti-HLA antibodies in the remaining two patients. Our study highlights the non-tolerability and poor efficacy of DFPP prior to antibody-incompatible kidney transplantation that limit its extensive use in the desensitization protocols.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=2;spage=297;epage=301;aulast=Hebibi |
| spellingShingle | Hadia Hebibi Hugo Weclawiak Lionel Rostaing Séverine Beaudreuil Asma Allal Hélène François Antoine Durrbach Nassim Kamar Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates Saudi Journal of Kidney Diseases and Transplantation |
| title | Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates |
| title_full | Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates |
| title_fullStr | Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates |
| title_full_unstemmed | Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates |
| title_short | Non-tolerability of double-filtration plasmapheresis in antibody-incompatible kidney transplant candidates |
| title_sort | non tolerability of double filtration plasmapheresis in antibody incompatible kidney transplant candidates |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2015;volume=26;issue=2;spage=297;epage=301;aulast=Hebibi |
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