Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study
We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolit...
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MDPI AG
2022-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/8/2475 |
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| author | Ekaterina V. Ilgisonis Raisa Shalina Nigyar Kasum-Zade Kristina G. Burkova Oxana P. Trifonova Dmitry L. Maslov Anna L. Kaysheva Sergey S. Markin |
| author_facet | Ekaterina V. Ilgisonis Raisa Shalina Nigyar Kasum-Zade Kristina G. Burkova Oxana P. Trifonova Dmitry L. Maslov Anna L. Kaysheva Sergey S. Markin |
| author_sort | Ekaterina V. Ilgisonis |
| collection | DOAJ |
| description | We sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress. |
| first_indexed | 2024-03-09T04:22:26Z |
| format | Article |
| id | doaj.art-eb76535f99be47a2a2ee2eff498dd3a6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:22:26Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-eb76535f99be47a2a2ee2eff498dd3a62023-12-03T13:46:22ZengMDPI AGMolecules1420-30492022-04-01278247510.3390/molecules27082475Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective StudyEkaterina V. Ilgisonis0Raisa Shalina1Nigyar Kasum-Zade2Kristina G. Burkova3Oxana P. Trifonova4Dmitry L. Maslov5Anna L. Kaysheva6Sergey S. Markin7V.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, RussiaDepartment of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ostrovitianov Str. 1, 117997 Moscow, RussiaDepartment of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ostrovitianov Str. 1, 117997 Moscow, RussiaDepartment of Obstetrics and Gynecology, Pirogov Russian National Research Medical University, Ostrovitianov Str. 1, 117997 Moscow, RussiaV.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, RussiaV.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, RussiaV.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, RussiaV.N. Orekhovich Institute of Biomedical Chemistry, 119121 Moscow, RussiaWe sought to identify the characteristic metabolite profile of blood plasma samples obtained from patients with preeclampsia. Direct high-resolution mass spectrometry was used to analyze samples from 79 pregnant women, 34 of whom had preeclampsia. We performed a comparative analysis of the metabolite profiles and found that they differed between pregnant women with and without preeclampsia. Lipids and sugars were identified as components of the metabolite profile that are likely to be associated with the development of preeclampsia. While PE was established only in the third trimester, a set of metabolites specific for the third trimester, including 2-(acetylamino)-1,5-anhydro-2-deoxy-4-O-b-D-galactopyranosyl-D-arabino-Hex-1-enitol, N-Acetyl-D-glucosaminyldiphosphodolichol, Cer(d18:0/20:0), and allolithocholic acid, was already traced in the first trimester. These components are also likely involved in lipid metabolism disorders and the development of oxidative stress.https://www.mdpi.com/1420-3049/27/8/2475preeclampsiametabolitesdigital medicinedirect mass spectrometry |
| spellingShingle | Ekaterina V. Ilgisonis Raisa Shalina Nigyar Kasum-Zade Kristina G. Burkova Oxana P. Trifonova Dmitry L. Maslov Anna L. Kaysheva Sergey S. Markin Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study Molecules preeclampsia metabolites digital medicine direct mass spectrometry |
| title | Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study |
| title_full | Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study |
| title_fullStr | Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study |
| title_full_unstemmed | Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study |
| title_short | Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study |
| title_sort | metabolomic markers for predicting preeclampsia in the first trimester of pregnancy a retrospective study |
| topic | preeclampsia metabolites digital medicine direct mass spectrometry |
| url | https://www.mdpi.com/1420-3049/27/8/2475 |
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