Regulation of Aldo-keto Reductases in Human Diseases
The aldo-keto reductases (AKRs) are a superfamily of NAD(P)H-linked oxidoreductases, which reduce aldehydes and ketones to their respective primary and secondary alcohols. AKR enzymes are increasingly being recognized to play an important role in the transformation and detoxification of aldehydes an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00035/full |
| _version_ | 1818494723301572608 |
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| author | Wei-Dong eChen Yanqiao eZhang |
| author_facet | Wei-Dong eChen Yanqiao eZhang |
| author_sort | Wei-Dong eChen |
| collection | DOAJ |
| description | The aldo-keto reductases (AKRs) are a superfamily of NAD(P)H-linked oxidoreductases, which reduce aldehydes and ketones to their respective primary and secondary alcohols. AKR enzymes are increasingly being recognized to play an important role in the transformation and detoxification of aldehydes and ketones generated endogenously and exogenously during drug detoxification and xenobiotic metabolism. Many transcription factors have been identified to regulate the expression of human AKR genes, which could have profound effects on the metabolism of endogenous mediators and detoxication of chemical carcinogens. This review summarizes the current knowledge of AKR regulation by transcription factors and other mediators in human diseases. |
| first_indexed | 2024-12-10T18:10:16Z |
| format | Article |
| id | doaj.art-eb77b9873eb94539bc3332c3f48bc2ea |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-10T18:10:16Z |
| publishDate | 2012-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-eb77b9873eb94539bc3332c3f48bc2ea2022-12-22T01:38:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122012-03-01310.3389/fphar.2012.0003520138Regulation of Aldo-keto Reductases in Human DiseasesWei-Dong eChen0Yanqiao eZhang1Northeast Ohio Medical UniversityNortheast Ohio Medical UniversityThe aldo-keto reductases (AKRs) are a superfamily of NAD(P)H-linked oxidoreductases, which reduce aldehydes and ketones to their respective primary and secondary alcohols. AKR enzymes are increasingly being recognized to play an important role in the transformation and detoxification of aldehydes and ketones generated endogenously and exogenously during drug detoxification and xenobiotic metabolism. Many transcription factors have been identified to regulate the expression of human AKR genes, which could have profound effects on the metabolism of endogenous mediators and detoxication of chemical carcinogens. This review summarizes the current knowledge of AKR regulation by transcription factors and other mediators in human diseases.http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00035/fullregulationtranscription factorHuman Diseasealdo-keto reductaseresponse element |
| spellingShingle | Wei-Dong eChen Yanqiao eZhang Regulation of Aldo-keto Reductases in Human Diseases Frontiers in Pharmacology regulation transcription factor Human Disease aldo-keto reductase response element |
| title | Regulation of Aldo-keto Reductases in Human Diseases |
| title_full | Regulation of Aldo-keto Reductases in Human Diseases |
| title_fullStr | Regulation of Aldo-keto Reductases in Human Diseases |
| title_full_unstemmed | Regulation of Aldo-keto Reductases in Human Diseases |
| title_short | Regulation of Aldo-keto Reductases in Human Diseases |
| title_sort | regulation of aldo keto reductases in human diseases |
| topic | regulation transcription factor Human Disease aldo-keto reductase response element |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00035/full |
| work_keys_str_mv | AT weidongechen regulationofaldoketoreductasesinhumandiseases AT yanqiaoezhang regulationofaldoketoreductasesinhumandiseases |