A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females
Diet plays a significant role in maintaining lifelong health. In particular, lowering the dietary protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect of these macronutrients on physiology. Using Drosophila melanogaster, we show that the role of protein and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/62335 |
| _version_ | 1828375708437577728 |
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| author | Brooke Zanco Christen K Mirth Carla M Sgrò Matthew DW Piper |
| author_facet | Brooke Zanco Christen K Mirth Carla M Sgrò Matthew DW Piper |
| author_sort | Brooke Zanco |
| collection | DOAJ |
| description | Diet plays a significant role in maintaining lifelong health. In particular, lowering the dietary protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect of these macronutrients on physiology. Using Drosophila melanogaster, we show that the role of protein and carbohydrate on lifespan is indirect, acting by altering the partitioning of limiting amounts of dietary sterols between reproduction and lifespan. Shorter lifespans in flies fed on high protein: carbohydrate diets can be rescued by supplementing their food with cholesterol. Not only does this fundamentally alter the way we interpret the mechanisms of lifespan extension by dietary restriction, these data highlight the important principle that life histories can be affected by nutrient-dependent trade-offs that are indirect and independent of the nutrients (often macronutrients) that are the focus of study. This brings us closer to understanding the mechanistic basis of dietary restriction. |
| first_indexed | 2024-04-14T07:51:18Z |
| format | Article |
| id | doaj.art-eb7891ab46b14b4bb33e735dca049a79 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:51:18Z |
| publishDate | 2021-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-eb7891ab46b14b4bb33e735dca049a792022-12-22T02:05:12ZengeLife Sciences Publications LtdeLife2050-084X2021-01-011010.7554/eLife.62335A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster femalesBrooke Zanco0https://orcid.org/0000-0001-7112-8640Christen K Mirth1https://orcid.org/0000-0002-9765-4021Carla M Sgrò2Matthew DW Piper3https://orcid.org/0000-0003-3245-7219Monash University, School of Biological Sciences, Clayton, AustraliaMonash University, School of Biological Sciences, Clayton, AustraliaMonash University, School of Biological Sciences, Clayton, AustraliaMonash University, School of Biological Sciences, Clayton, AustraliaDiet plays a significant role in maintaining lifelong health. In particular, lowering the dietary protein: carbohydrate ratio can improve lifespan. This has been interpreted as a direct effect of these macronutrients on physiology. Using Drosophila melanogaster, we show that the role of protein and carbohydrate on lifespan is indirect, acting by altering the partitioning of limiting amounts of dietary sterols between reproduction and lifespan. Shorter lifespans in flies fed on high protein: carbohydrate diets can be rescued by supplementing their food with cholesterol. Not only does this fundamentally alter the way we interpret the mechanisms of lifespan extension by dietary restriction, these data highlight the important principle that life histories can be affected by nutrient-dependent trade-offs that are indirect and independent of the nutrients (often macronutrients) that are the focus of study. This brings us closer to understanding the mechanistic basis of dietary restriction.https://elifesciences.org/articles/62335lifespannutritionsterolsdietary restrictionmicronutrientsmacronutrients |
| spellingShingle | Brooke Zanco Christen K Mirth Carla M Sgrò Matthew DW Piper A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females eLife lifespan nutrition sterols dietary restriction micronutrients macronutrients |
| title | A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females |
| title_full | A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females |
| title_fullStr | A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females |
| title_full_unstemmed | A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females |
| title_short | A dietary sterol trade-off determines lifespan responses to dietary restriction in Drosophila melanogaster females |
| title_sort | dietary sterol trade off determines lifespan responses to dietary restriction in drosophila melanogaster females |
| topic | lifespan nutrition sterols dietary restriction micronutrients macronutrients |
| url | https://elifesciences.org/articles/62335 |
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