18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis
The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/2/123 |
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| author | Tetiana Skrypets Cristina Ferrari Luca Nassi Gloria Margiotta Casaluci Benedetta Puccini Lara Mannelli Kateryna Filonenko Irina Kryachok Felice Clemente Maria Carmela Vegliante Antonella Daniele Gianmauro Sacchetti Attilio Guarini Carla Minoia |
| author_facet | Tetiana Skrypets Cristina Ferrari Luca Nassi Gloria Margiotta Casaluci Benedetta Puccini Lara Mannelli Kateryna Filonenko Irina Kryachok Felice Clemente Maria Carmela Vegliante Antonella Daniele Gianmauro Sacchetti Attilio Guarini Carla Minoia |
| author_sort | Tetiana Skrypets |
| collection | DOAJ |
| description | The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In our retrospective cohort of 79 patients, sensitivity and specificity of 18F-FDG PET/CT were low for the stomach, with a fair concordance (<i>k</i> = 0.32), while higher concordance with pathologic results (<i>k</i> = 0.65) was detected in the colorectal tract. Thus, gastric biopsy remains helpful in the staging of MCL despite 18F-FDG PET/CT, while colonoscopy could be omitted in asymptomatic patients. The validation of our data in prospective cohorts is desirable |
| first_indexed | 2024-03-09T00:54:02Z |
| format | Article |
| id | doaj.art-eb7c231c79fa4218ae47c996f1baac2d |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T00:54:02Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-eb7c231c79fa4218ae47c996f1baac2d2023-12-11T17:00:58ZengMDPI AGJournal of Personalized Medicine2075-44262021-02-0111212310.3390/jpm1102012318F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort AnalysisTetiana Skrypets0Cristina Ferrari1Luca Nassi2Gloria Margiotta Casaluci3Benedetta Puccini4Lara Mannelli5Kateryna Filonenko6Irina Kryachok7Felice Clemente8Maria Carmela Vegliante9Antonella Daniele10Gianmauro Sacchetti11Attilio Guarini12Carla Minoia13Haematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyD.I.M.—Diagnostic Imaging-Nuclear Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyHaematology Department, Azienda Ospedaliero-Universitaria Maggiore della Carità, 28100 Novara, ItalyHaematology Department, Azienda Ospedaliero-Universitaria Maggiore della Carità, 28100 Novara, ItalyHematology Department, Azienda Ospedaliera Careggi, 50139 Firenze, ItalyHematology Department, Azienda Ospedaliera Careggi, 50139 Firenze, ItalyOncohematology Department, National Cancer Institute, 03022 Kyiv, UkraineOncohematology Department, National Cancer Institute, 03022 Kyiv, UkraineHaematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyHaematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyExperimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyNuclear Medicine, AOU Maggiore della Carità, 28100 Novara, ItalyHaematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyHaematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyThe detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In our retrospective cohort of 79 patients, sensitivity and specificity of 18F-FDG PET/CT were low for the stomach, with a fair concordance (<i>k</i> = 0.32), while higher concordance with pathologic results (<i>k</i> = 0.65) was detected in the colorectal tract. Thus, gastric biopsy remains helpful in the staging of MCL despite 18F-FDG PET/CT, while colonoscopy could be omitted in asymptomatic patients. The validation of our data in prospective cohorts is desirablehttps://www.mdpi.com/2075-4426/11/2/123Mantle Cell Lymphomastagingendoscopygastric biopsycolorectal biopsy18F-FDG PET/CT |
| spellingShingle | Tetiana Skrypets Cristina Ferrari Luca Nassi Gloria Margiotta Casaluci Benedetta Puccini Lara Mannelli Kateryna Filonenko Irina Kryachok Felice Clemente Maria Carmela Vegliante Antonella Daniele Gianmauro Sacchetti Attilio Guarini Carla Minoia 18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis Journal of Personalized Medicine Mantle Cell Lymphoma staging endoscopy gastric biopsy colorectal biopsy 18F-FDG PET/CT |
| title | 18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis |
| title_full | 18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis |
| title_fullStr | 18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis |
| title_full_unstemmed | 18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis |
| title_short | 18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis |
| title_sort | 18f fdg pet ct cannot substitute endoscopy in the staging of gastrointestinal involvement in mantle cell lymphoma a retrospective multi center cohort analysis |
| topic | Mantle Cell Lymphoma staging endoscopy gastric biopsy colorectal biopsy 18F-FDG PET/CT |
| url | https://www.mdpi.com/2075-4426/11/2/123 |
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