Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1<sup>s/s</sup>α2<sup>s/s</sup> Mouse Model of High Affinity for Cardiotonic Steroids

Cardiac Oxidative Signaling and Physiological Hypertrophy in the Na/K-ATPase α1<sup>s/s</sup>α2<sup>s/s</sup> Mouse Model of High Affinity for Cardiotonic Steroids

The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in the treatment of cardiac conditions, CTS inhibit the ion-pumping function of Na/K-ATPase. At much lower concentrations, in the range of those reported for en...

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Bibliographic Details
Main Authors: Pauline V. Marck, Marco T. Pessoa, Yunhui Xu, Laura C. Kutz, Dominic M. Collins, Yanling Yan, Cierra King, Xiaoliang Wang, Qiming Duan, Liquan Cai, Jeffrey X. Xie, Jerry B. Lingrel, Zijian Xie, Jiang Tian, Sandrine V. Pierre
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
Na/K-ATPase
cardiotonic steroids
isoform
reactive oxygen species
hypertrophy
Online Access:https://www.mdpi.com/1422-0067/22/7/3462

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https://www.mdpi.com/1422-0067/22/7/3462

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