Effect of an antiviral and vitamins A, C, D on dopamine and some oxidative stress markers in rat brain exposed to ozone
We measured the effect of an antiviral drug and vitamins on dopamine, 5-HIAA and some oxidative biomarkers in the brain of rats exposed to ozone. Groups of Wistar rats received intraperitoneally for 5 days: G1 (control) - 0.9% NaCl; G2 - oseltamivir (an antiviral); G3 - multivitamins (vitam...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
University of Belgrade, University of Novi Sad
2013-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641304371G.pdf |
| Summary: | We measured the effect of an antiviral drug and vitamins on dopamine, 5-HIAA
and some oxidative biomarkers in the brain of rats exposed to ozone. Groups
of Wistar rats received intraperitoneally for 5 days: G1 (control) - 0.9%
NaCl; G2 - oseltamivir (an antiviral); G3 - multivitamins (vitamins A, C and
D). A similar assay was realized in rats exposed to ozone. The brain was
excised and dissected into the cortex, hemispheres, cerebellum and
medulla/oblongata to measure the levels dopamine, GSH and lipid peroxidation.
Levels of 5-HIAA increased in the cerebellum/medulla oblongata of rats that
received vitamins and ozone. Dopamine increased in all regions of the groups
that received oseltamivir in the presence of ozone. GSH increased in the
hemispheres and cerebellum/medulla oblongata only in groups that received
oseltamivir and ozone. We found that vitamins and oseltamivir altered
serotonin metabolism in the brains of young rats. Oxidative stress may be
involved in these effects. |
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| ISSN: | 0354-4664 1821-4339 |