Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm
A body of animal and human evidence points to the norepinephrine (NE) locus coeruleus (LC) system in modulating memory for arousing experiences, but whether the LC would recast its role along memory stages remains unknown. Sedation precluded examination of LC dynamics during memory processing in ani...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2020-06-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/52059 |
| _version_ | 1811236158482415616 |
|---|---|
| author | Heidi IL Jacobs Nikos Priovoulos Benedikt A Poser Linda HG Pagen Dimo Ivanov Frans RJ Verhey Kâmil Uludağ |
| author_facet | Heidi IL Jacobs Nikos Priovoulos Benedikt A Poser Linda HG Pagen Dimo Ivanov Frans RJ Verhey Kâmil Uludağ |
| author_sort | Heidi IL Jacobs |
| collection | DOAJ |
| description | A body of animal and human evidence points to the norepinephrine (NE) locus coeruleus (LC) system in modulating memory for arousing experiences, but whether the LC would recast its role along memory stages remains unknown. Sedation precluded examination of LC dynamics during memory processing in animals. Here, we addressed the contribution of the LC during arousal-associated memory processing through a unique combination of dedicated ultra-high-field LC-imaging methods, a well-established emotional memory task, online physiological and saliva alpha-amylase measurements in young adults. Arousal-related LC activation followed amygdala engagement during encoding. During consolidation and recollection, activation transitioned to hippocampal involvement, reflecting learning and model updating. NE-LC activation is dynamic, plays an arousal-controlling role, and is not sufficient but requires interactions with the amygdala to form adaptive memories of emotional experiences. These findings have implications for understanding contributions of LC dysregulation to disruptions in emotional memory formation, observed in psychiatric and neurocognitive disorders. |
| first_indexed | 2024-04-12T12:04:05Z |
| format | Article |
| id | doaj.art-eb88ec82ddf3497e8b7b2a1585bc92b2 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:04:05Z |
| publishDate | 2020-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-eb88ec82ddf3497e8b7b2a1585bc92b22022-12-22T03:33:45ZengeLife Sciences Publications LtdeLife2050-084X2020-06-01910.7554/eLife.52059Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigmHeidi IL Jacobs0https://orcid.org/0000-0001-7620-3822Nikos Priovoulos1Benedikt A Poser2Linda HG Pagen3Dimo Ivanov4Frans RJ Verhey5Kâmil Uludağ6Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, United States; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, Netherlands; Faculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, NetherlandsFaculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, NetherlandsFaculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, NetherlandsFaculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, NetherlandsFaculty of Psychology and Neuroscience, Department of Cognitive Neuroscience, Maastricht University, Maastricht, NetherlandsFaculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, NetherlandsCenter for Neuroscience Imaging Research, Institute for Basic Science and Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea; Techna Institute & Koerner Scientist in MR Imaging, University Health Network, Toronto, CanadaA body of animal and human evidence points to the norepinephrine (NE) locus coeruleus (LC) system in modulating memory for arousing experiences, but whether the LC would recast its role along memory stages remains unknown. Sedation precluded examination of LC dynamics during memory processing in animals. Here, we addressed the contribution of the LC during arousal-associated memory processing through a unique combination of dedicated ultra-high-field LC-imaging methods, a well-established emotional memory task, online physiological and saliva alpha-amylase measurements in young adults. Arousal-related LC activation followed amygdala engagement during encoding. During consolidation and recollection, activation transitioned to hippocampal involvement, reflecting learning and model updating. NE-LC activation is dynamic, plays an arousal-controlling role, and is not sufficient but requires interactions with the amygdala to form adaptive memories of emotional experiences. These findings have implications for understanding contributions of LC dysregulation to disruptions in emotional memory formation, observed in psychiatric and neurocognitive disorders.https://elifesciences.org/articles/52059Locus coeruleusnorepinephrinearousalmemoryultra-high-fieldautonomic tone |
| spellingShingle | Heidi IL Jacobs Nikos Priovoulos Benedikt A Poser Linda HG Pagen Dimo Ivanov Frans RJ Verhey Kâmil Uludağ Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm eLife Locus coeruleus norepinephrine arousal memory ultra-high-field autonomic tone |
| title | Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm |
| title_full | Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm |
| title_fullStr | Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm |
| title_full_unstemmed | Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm |
| title_short | Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm |
| title_sort | dynamic behavior of the locus coeruleus during arousal related memory processing in a multi modal 7t fmri paradigm |
| topic | Locus coeruleus norepinephrine arousal memory ultra-high-field autonomic tone |
| url | https://elifesciences.org/articles/52059 |
| work_keys_str_mv | AT heidiiljacobs dynamicbehaviorofthelocuscoeruleusduringarousalrelatedmemoryprocessinginamultimodal7tfmriparadigm AT nikospriovoulos dynamicbehaviorofthelocuscoeruleusduringarousalrelatedmemoryprocessinginamultimodal7tfmriparadigm AT benediktaposer dynamicbehaviorofthelocuscoeruleusduringarousalrelatedmemoryprocessinginamultimodal7tfmriparadigm AT lindahgpagen dynamicbehaviorofthelocuscoeruleusduringarousalrelatedmemoryprocessinginamultimodal7tfmriparadigm AT dimoivanov dynamicbehaviorofthelocuscoeruleusduringarousalrelatedmemoryprocessinginamultimodal7tfmriparadigm AT fransrjverhey dynamicbehaviorofthelocuscoeruleusduringarousalrelatedmemoryprocessinginamultimodal7tfmriparadigm AT kamiluludag dynamicbehaviorofthelocuscoeruleusduringarousalrelatedmemoryprocessinginamultimodal7tfmriparadigm |