TMEM16 scramblases thin the membrane to enable lipid scrambling
Lipid scrambling is required for many cellular processes but the lipid-protein interactions that occur during transport are unknown. Using cryoEM and biochemical assays the authors show that membrane thinning is critical for lipid flipping.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30300-z |
| _version_ | 1818201315343335424 |
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| author | Maria E. Falzone Zhang Feng Omar E. Alvarenga Yangang Pan ByoungCheol Lee Xiaolu Cheng Eva Fortea Simon Scheuring Alessio Accardi |
| author_facet | Maria E. Falzone Zhang Feng Omar E. Alvarenga Yangang Pan ByoungCheol Lee Xiaolu Cheng Eva Fortea Simon Scheuring Alessio Accardi |
| author_sort | Maria E. Falzone |
| collection | DOAJ |
| description | Lipid scrambling is required for many cellular processes but the lipid-protein interactions that occur during transport are unknown. Using cryoEM and biochemical assays the authors show that membrane thinning is critical for lipid flipping. |
| first_indexed | 2024-12-12T02:51:36Z |
| format | Article |
| id | doaj.art-eb89ec895ead4ea1bd22a27cf17cce5f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T02:51:36Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-eb89ec895ead4ea1bd22a27cf17cce5f2022-12-22T00:40:52ZengNature PortfolioNature Communications2041-17232022-05-0113111410.1038/s41467-022-30300-zTMEM16 scramblases thin the membrane to enable lipid scramblingMaria E. Falzone0Zhang Feng1Omar E. Alvarenga2Yangang Pan3ByoungCheol Lee4Xiaolu Cheng5Eva Fortea6Simon Scheuring7Alessio Accardi8Department of Anesthesiology, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeDepartment of Physiology and Biophysics, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeDepartment of Anesthesiology, Weill Cornell Medical CollegeLipid scrambling is required for many cellular processes but the lipid-protein interactions that occur during transport are unknown. Using cryoEM and biochemical assays the authors show that membrane thinning is critical for lipid flipping.https://doi.org/10.1038/s41467-022-30300-z |
| spellingShingle | Maria E. Falzone Zhang Feng Omar E. Alvarenga Yangang Pan ByoungCheol Lee Xiaolu Cheng Eva Fortea Simon Scheuring Alessio Accardi TMEM16 scramblases thin the membrane to enable lipid scrambling Nature Communications |
| title | TMEM16 scramblases thin the membrane to enable lipid scrambling |
| title_full | TMEM16 scramblases thin the membrane to enable lipid scrambling |
| title_fullStr | TMEM16 scramblases thin the membrane to enable lipid scrambling |
| title_full_unstemmed | TMEM16 scramblases thin the membrane to enable lipid scrambling |
| title_short | TMEM16 scramblases thin the membrane to enable lipid scrambling |
| title_sort | tmem16 scramblases thin the membrane to enable lipid scrambling |
| url | https://doi.org/10.1038/s41467-022-30300-z |
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