Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt
Abstract Background The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 had consistently been reported as risk factors for unfavorable outcome. We aimed to evaluate the impact of como...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-08-01
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| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-022-00530-5 |
| _version_ | 1798042564424630272 |
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| author | Eman M. Khedr Enas Daef Aliae Mohamed-Hussein Ehab F. Mostafa Mohamed Zein Sahar M. Hassany Hanan Galal Shimaa Abbas Hassan Islam Galal Amro A. Zarzour Hebatallah M. Hassan Mariam Taher Amin Maiada K. Hashem Khaled Osama Ayman Gamea |
| author_facet | Eman M. Khedr Enas Daef Aliae Mohamed-Hussein Ehab F. Mostafa Mohamed Zein Sahar M. Hassany Hanan Galal Shimaa Abbas Hassan Islam Galal Amro A. Zarzour Hebatallah M. Hassan Mariam Taher Amin Maiada K. Hashem Khaled Osama Ayman Gamea |
| author_sort | Eman M. Khedr |
| collection | DOAJ |
| description | Abstract Background The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 had consistently been reported as risk factors for unfavorable outcome. We aimed to evaluate the impact of comorbidities in COVID-19 patients on the outcome and determine predictors of prolonged hospital stay, requisite for intensive care unit (ICU) admission. Four hundred and thirty-nine adult patients who are admitted through (June and July 2020) in our University Hospitals were included in the study. All participants were diagnosed with COVID-19 according to Egyptian Ministry of Health guidance as definite case or probable case. Results Patients with comorbidities represented 61.7% of all cases. Constitutional symptoms especially myalgia and lower respiratory tract (LRT) symptoms such as dyspnea were significantly higher in patients with comorbidities (P < 0.05). Patients with comorbidities had significantly worse laboratory parameters. ICU admission was higher in patients with comorbidities (35.8%). Among different comorbidities 45.4% of cardiovascular diseases (CVD) cases were admitted in ICU followed by diabetes mellitus (DM) cases (40.8%). Also, patients with comorbidities needed invasive mechanical ventilation more than those without comorbidity (31 versus 10.7%, P < 0.001). Significant lower frequency of recovery was found in COVID-19 patients with comorbidities (59% versus 81%, P < 0.001) and death rate was significantly higher in cases with comorbidities (P < 0.001). The survival rates in cases with pre-existing CVD and neurological diseases were lower than those without disease (P < 0.002 and 0.001, respectively). Conclusions Association of cardiovascular comorbid conditions including hypertension or neurological diseases including old cerebrovascular strokes together with COVID-19 infections carries higher risks of mortality. However, other comorbidities such as diabetes mellitus, chronic pulmonary or kidney diseases may also contribute to increased COVID-19 severity. |
| first_indexed | 2024-04-11T22:37:12Z |
| format | Article |
| id | doaj.art-eb8a6f33dd7a49f1a4877347df5b2c72 |
| institution | Directory Open Access Journal |
| issn | 1687-8329 |
| language | English |
| last_indexed | 2024-04-11T22:37:12Z |
| publishDate | 2022-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj.art-eb8a6f33dd7a49f1a4877347df5b2c722022-12-22T03:59:11ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292022-08-0158111210.1186/s41983-022-00530-5Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper EgyptEman M. Khedr0Enas Daef1Aliae Mohamed-Hussein2Ehab F. Mostafa3Mohamed Zein4Sahar M. Hassany5Hanan Galal6Shimaa Abbas Hassan7Islam Galal8Amro A. Zarzour9Hebatallah M. Hassan10Mariam Taher Amin11Maiada K. Hashem12Khaled Osama13Ayman Gamea14Department of Neurology and Psychiatry, Assiut UniversityDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut UniversityDepartment of Chest, Faculty of Medicine, Assiut UniversityDepartment of Tropical Medicine and Gastroenterology, Alrajhi University Hospital, Assiut UniversityDepartment of Internal Medicine, Assiut UniversityDepartment of Tropical Medicine and Gastroenterology, Alrajhi University Hospital, Assiut UniversityClinical Pathology Labs, General Chest HospitalDepartment of Anesthesia and Intensive Care, Assiut UniversityDepartment of Chest, Faculty of Medicine, Aswan UniversityDepartment of Anesthesia and Intensive Care, Assiut UniversityDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut UniversityDepartment of Public Health, Assiut UniversityDepartment of Chest, Faculty of Medicine, Assiut UniversityDepartment of Neurology and Psychiatry, Assiut UniversityDepartment of Neurology and Psychiatry, South Valley UniversityAbstract Background The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 had consistently been reported as risk factors for unfavorable outcome. We aimed to evaluate the impact of comorbidities in COVID-19 patients on the outcome and determine predictors of prolonged hospital stay, requisite for intensive care unit (ICU) admission. Four hundred and thirty-nine adult patients who are admitted through (June and July 2020) in our University Hospitals were included in the study. All participants were diagnosed with COVID-19 according to Egyptian Ministry of Health guidance as definite case or probable case. Results Patients with comorbidities represented 61.7% of all cases. Constitutional symptoms especially myalgia and lower respiratory tract (LRT) symptoms such as dyspnea were significantly higher in patients with comorbidities (P < 0.05). Patients with comorbidities had significantly worse laboratory parameters. ICU admission was higher in patients with comorbidities (35.8%). Among different comorbidities 45.4% of cardiovascular diseases (CVD) cases were admitted in ICU followed by diabetes mellitus (DM) cases (40.8%). Also, patients with comorbidities needed invasive mechanical ventilation more than those without comorbidity (31 versus 10.7%, P < 0.001). Significant lower frequency of recovery was found in COVID-19 patients with comorbidities (59% versus 81%, P < 0.001) and death rate was significantly higher in cases with comorbidities (P < 0.001). The survival rates in cases with pre-existing CVD and neurological diseases were lower than those without disease (P < 0.002 and 0.001, respectively). Conclusions Association of cardiovascular comorbid conditions including hypertension or neurological diseases including old cerebrovascular strokes together with COVID-19 infections carries higher risks of mortality. However, other comorbidities such as diabetes mellitus, chronic pulmonary or kidney diseases may also contribute to increased COVID-19 severity.https://doi.org/10.1186/s41983-022-00530-5ComorbiditiesCOVID-19Upper EgyptCardiovascular diseasesNeurological diseasesChronic pulmonary diseases |
| spellingShingle | Eman M. Khedr Enas Daef Aliae Mohamed-Hussein Ehab F. Mostafa Mohamed Zein Sahar M. Hassany Hanan Galal Shimaa Abbas Hassan Islam Galal Amro A. Zarzour Hebatallah M. Hassan Mariam Taher Amin Maiada K. Hashem Khaled Osama Ayman Gamea Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Comorbidities COVID-19 Upper Egypt Cardiovascular diseases Neurological diseases Chronic pulmonary diseases |
| title | Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt |
| title_full | Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt |
| title_fullStr | Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt |
| title_full_unstemmed | Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt |
| title_short | Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt |
| title_sort | comorbidities and outcomes among patients hospitalized with covid 19 in upper egypt |
| topic | Comorbidities COVID-19 Upper Egypt Cardiovascular diseases Neurological diseases Chronic pulmonary diseases |
| url | https://doi.org/10.1186/s41983-022-00530-5 |
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