Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes
Abstract Objectives Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia and metabolic stress, involved in the stepwise development of cardiovascular complications. Fibroblast growth factor 21 (FGF21) is a novel hepatokine involved in regulating gluc...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01523-y |
| _version_ | 1797397981382574080 |
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| author | Zhen Liu Yue Peng Supeng Li Yusheng Lin Yunfeng Huang Wenting Chen Chunhua Bao Zengxian Zhou Zhuofeng Lin Liangmiao Chen |
| author_facet | Zhen Liu Yue Peng Supeng Li Yusheng Lin Yunfeng Huang Wenting Chen Chunhua Bao Zengxian Zhou Zhuofeng Lin Liangmiao Chen |
| author_sort | Zhen Liu |
| collection | DOAJ |
| description | Abstract Objectives Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia and metabolic stress, involved in the stepwise development of cardiovascular complications. Fibroblast growth factor 21 (FGF21) is a novel hepatokine involved in regulating glucose and lipid metabolism, and has been linked to the prediction, treatment, and improvement of prognosis in multiple cardiovascular diseases (CVDs). The aim of this study is to explore the relationship between FGF21 levels and vascular diseases (VDs) including carotid atherosclerosis (CAS) and hypertension (HP) in patients with T2DM. Methods Baseline serum FGF21 was determined in a cross-sectional study of 701 patients with T2DM and 258 healthy control. Results The morbidity of CAS was increased in T2DM patients with HP as compared with those without (p < 0.001). The average serum FGF21 level of healthy was [123.9 (67.2-219.3)]. Baseline FGF21 was significantly higher in those who developed CAS or HP than in those who did not [305.9 (177.2-508.4) vs. 197.2 (129.7-308.3) pg/mL, p < 0.001]. In addition, an elevated serum FGF21 was observed in T2DM patients with HP and CAS than that of T2DM patients with CAS or HP [550.5 (312.6-711.3) vs. 305.9 pg/mL, p < 0.001]. Serum FGF21 levels were positively correlated with body mass index and carotid intima media thicknes (p < 0.05), the association remained significant after adjusting for age and T2DM duration. Furthermore, the multinomial logistic regression showed that serum FGF21 was independently associated with CAS and HP in patients with T2DM after adjustment for demographic and traditional VDs risk factors (p < 0.001). Conclusions Baseline FGF21 is elevated in VDs during diabetes, changes of serum FGF21 levels were appropriately matched to metabolic stress. FGF21can be used as an independent predictor for diagnosing VDs and predicting prognosis. |
| first_indexed | 2024-03-09T01:18:06Z |
| format | Article |
| id | doaj.art-eb8b5975bb05484ea4e2079e305c57f3 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-09T01:18:06Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-eb8b5975bb05484ea4e2079e305c57f32023-12-10T12:21:44ZengBMCBMC Endocrine Disorders1472-68232023-12-0123111010.1186/s12902-023-01523-yIncreased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetesZhen Liu0Yue Peng1Supeng Li2Yusheng Lin3Yunfeng Huang4Wenting Chen5Chunhua Bao6Zengxian Zhou7Zhuofeng Lin8Liangmiao Chen9School of Pharmaceutical College, Wenzhou Medical UniversityDepartment of Cardiology, The 1st affiliated Hospital of Wenzhou Medical UnversitySchool of Pharmaceutical College, Wenzhou Medical UniversityDepartment of Cardiology, The 1st affiliated Hospital of Wenzhou Medical UnversityDepartment of Cardiology, The 1st affiliated Hospital of Wenzhou Medical UnversityDepartment of Endocrinology, The 3rd affiliated Hospital of Wenzhou Medical University (Ruian People’s HospitalDepartment of Endocrinology, The 3rd affiliated Hospital of Wenzhou Medical University (Ruian People’s HospitalSchool of Pharmaceutical College, Wenzhou Medical UniversitySchool of Pharmaceutical College, Wenzhou Medical UniversityDepartment of Endocrinology, The 3rd affiliated Hospital of Wenzhou Medical University (Ruian People’s HospitalAbstract Objectives Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia and metabolic stress, involved in the stepwise development of cardiovascular complications. Fibroblast growth factor 21 (FGF21) is a novel hepatokine involved in regulating glucose and lipid metabolism, and has been linked to the prediction, treatment, and improvement of prognosis in multiple cardiovascular diseases (CVDs). The aim of this study is to explore the relationship between FGF21 levels and vascular diseases (VDs) including carotid atherosclerosis (CAS) and hypertension (HP) in patients with T2DM. Methods Baseline serum FGF21 was determined in a cross-sectional study of 701 patients with T2DM and 258 healthy control. Results The morbidity of CAS was increased in T2DM patients with HP as compared with those without (p < 0.001). The average serum FGF21 level of healthy was [123.9 (67.2-219.3)]. Baseline FGF21 was significantly higher in those who developed CAS or HP than in those who did not [305.9 (177.2-508.4) vs. 197.2 (129.7-308.3) pg/mL, p < 0.001]. In addition, an elevated serum FGF21 was observed in T2DM patients with HP and CAS than that of T2DM patients with CAS or HP [550.5 (312.6-711.3) vs. 305.9 pg/mL, p < 0.001]. Serum FGF21 levels were positively correlated with body mass index and carotid intima media thicknes (p < 0.05), the association remained significant after adjusting for age and T2DM duration. Furthermore, the multinomial logistic regression showed that serum FGF21 was independently associated with CAS and HP in patients with T2DM after adjustment for demographic and traditional VDs risk factors (p < 0.001). Conclusions Baseline FGF21 is elevated in VDs during diabetes, changes of serum FGF21 levels were appropriately matched to metabolic stress. FGF21can be used as an independent predictor for diagnosing VDs and predicting prognosis.https://doi.org/10.1186/s12902-023-01523-yFibroblast growth factor 21Vascular DiseasesCarotid AtherosclerosisHypertensionType 2 Diabetes Mellitus |
| spellingShingle | Zhen Liu Yue Peng Supeng Li Yusheng Lin Yunfeng Huang Wenting Chen Chunhua Bao Zengxian Zhou Zhuofeng Lin Liangmiao Chen Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes BMC Endocrine Disorders Fibroblast growth factor 21 Vascular Diseases Carotid Atherosclerosis Hypertension Type 2 Diabetes Mellitus |
| title | Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes |
| title_full | Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes |
| title_fullStr | Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes |
| title_full_unstemmed | Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes |
| title_short | Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes |
| title_sort | increased circulating fgf21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes |
| topic | Fibroblast growth factor 21 Vascular Diseases Carotid Atherosclerosis Hypertension Type 2 Diabetes Mellitus |
| url | https://doi.org/10.1186/s12902-023-01523-y |
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